Polypharmacy including falls risk-increasing medications and subsequent falls in community-dwelling middle-aged and older adults.
Background: polypharmacy is an important risk factor for falls, but recent studies suggest only when including medications associated with increasing the risk of falls.Design: a prospective, population-based cohort study.Subjects: 6,666 adults aged ≥50 years from The Irish Longitudinal study on Agei...
| Publicado en: | Age & Ageing Vol. 44; no. 1; pp. 90 - 97 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=100221892&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 100221892 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jan2015 vid: 44 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 100221892 10.1093/ageing/afu141 ppf: 90 ppct: 7 formats: tig: atl: Polypharmacy including falls risk-increasing medications and subsequent falls in community-dwelling middle-aged and older adults. aug: au: Richardson, Kathryn Bennett, Kathleen Kenny, Rose Anne affil: Department of Medical Gerontology , Trinity College Dublin , Dublin , Ireland The Irish Longitudinal Study on Ageing, Chemistry Extension Building, Trinity College Dublin , Dublin , Ireland Department of Pharmacology and Therapeutics , Trinity College Dublin , Dublin , Ireland Trinity College Institute of Neuroscience , Trinity College Dublin , Dublin , Ireland su: Ireland Psychological tests Old age Risk factors of falling down Antidepressants Benzodiazepines Drug therapy Confidence intervals Regression analysis Research funding Tranquilizing drugs Independent living Polypharmacy Data analysis software Descriptive statistics Odds ratio sug: subj: Psychological tests Old age Ireland Pharmaceutical and medicine manufacturing Medicinal and Botanical Manufacturing Risk factors of falling down Antidepressants Benzodiazepines Drug therapy Confidence intervals Regression analysis Research funding Tranquilizing drugs Independent living Polypharmacy Data analysis software Descriptive statistics Odds ratio keyword: drug therapy falls older people polypharmacy drug therapy falls older people polypharmacy ab: Background: polypharmacy is an important risk factor for falls, but recent studies suggest only when including medications associated with increasing the risk of falls.Design: a prospective, population-based cohort study.Subjects: 6,666 adults aged ≥50 years from The Irish Longitudinal study on Ageing.Methods: participants reported regular medication use at baseline. Any subsequent falls, any injurious falls and the number of falls were reported 2 years later. The association between polypharmacy (>4 medications) or fall risk-increasing medications and subsequent falls or injurious falls was assessed using modified Poisson regression. The association with the number of falls was assessed using negative binomial regression.Results: during follow-up, 231 falls per 1,000 person-years were reported. Polypharmacy including antidepressants was associated with a greater risk of any fall (adjusted relative risk (aRR) 1.28, 95% CI 1.06–1.54), of injurious falls (aRR 1.51, 95% CI 1.10–2.07) and a greater number of falls (adjusted incident rate ratio (aIRR) 1.60, 95% CI 1.19–2.15), but antidepressant use without polypharmacy and polypharmacy without antidepressants were not. The use of benzodiazepines was associated with injurious falls when coupled with polypharmacy (aRR 1.40, 95% CI 1.04–1.87), but was associated with a greater number of falls (aIRR 1.32, 95% CI 1.05–1.65), independent of polypharmacy. Other medications assessed, including antihypertensives, diuretics and antipsychotics, were not associated with outcomes.Conclusion: in middle-aged and older adults, polypharmacy, including antidepressant or benzodiazepine use, was associated with injurious falls and a greater number of falls. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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