Plasma YKL-40 in Inuit and Danes.
Aims: The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit. Methods: Plasma YKL-40 levels...
| Publicado en: | Alcohol & Alcoholism Vol. 50; no. 1; pp. 11 - 18 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Jan/Feb2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=100222187&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 100222187 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Jan/Feb2015 vid: 50 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 100222187 103867928 103867928 100222187 ppf: 11 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Plasma YKL-40 in Inuit and Danes. aug: au: Nøjgaard, Camilla Johansen, Julia S. Bjerregaard, Peter Bojesen, Stig E. Becker, Ulrik affil: Gastrounit, Medical Division , Copenhagen University Hospital Hvidovre , Hvidovre , Denmark sug: subj: Alcoholism Epidemiology Genomics Nutrition Greenland Denmark Human Cross Sectional Studies Academic Medical Centers Hematologic Tests Questionnaires Interviews Enzyme-Linked Immunosorbent Assay Data Analysis Software Male Female Adult Middle Age Aged Aged, 80 and Over Descriptive Statistics Confidence Intervals Linear Regression Multivariate Analysis Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Aims: The aim of the present study was to investigate whether there are differences in plasma levels of YKL-40 between Inuit in Greenland and in Denmark and in Danes, as well as to study the relationship between alcohol intake, plasma YKL-40 and other factors in Inuit. Methods: Plasma YKL-40 levels were measured on 1645 people from The Greenland Population Study (a cross-sectional population study of Inuit from Denmark and West Greenland) and were compared with the plasma YKL-40 levels of 8899 people from The Copenhagen City Heart Study (a population-based, prospective study of the Danish general population). Results: The plasma concentrations of YKL-40 were significantly (P = 0.001) lower in Inuit living in Greenland (median 46 µg/l, range 10–2164, n = 1164) compared with the plasma YKL-40 levels of Inuit living in Denmark (median 63 µg/l, range 20–2827, n = 481) and of Danes living in Denmark (median 55 µg/l, range 10–2909, n = 8899). In Inuit, increased alcohol intake was significantly associated with increased plasma YKL-40 levels (P < 0.001), and high plasma YKL-40 levels were associated with high values of alkaline phosphatase and low values of albumin. Smoking, gender and bilirubin were not associated with the plasma YKL-40 level. High levels of YKL-40 and alcohol were associated with where people lived. Conclusion: The plasma concentrations of YKL-40 are significantly lower in Inuit living in Greenland than Inuit and Danes living in Denmark. A number of factors, including different alcohol intake patterns, nutrition and genes may play a role in these findings. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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