Alterations in Pain Response are Partially Reversed by Methylphenidate (Ritalin) in Adults with Attention Deficit Hyperactivity Disorder ( ADHD).
Background Attention deficit hyperactivity disorder ( ADHD) is characterized by dysregulation of sensory processing and neurobiology of dopamine. Although cumulative evidence suggests that dopamine is involved in pain processing, pain perception in ADHD subjects and the effect of dopamine agonists s...
| Publicado en: | Pain Practice Vol. 15; no. 1; pp. 4 - 12 |
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| Autores principales: | , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=100256865&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 100256865 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307085 HYN jtl: Pain Practice issn: 15307085 maglogo: Y pubinfo: dt: Jan2015 vid: 15 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 100256865 103870419 103870419 10.1111/papr.12129 100256865 ppf: 4 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Alterations in Pain Response are Partially Reversed by Methylphenidate (Ritalin) in Adults with Attention Deficit Hyperactivity Disorder ( ADHD). aug: au: Treister, Roi Eisenberg, Elon Demeter, Naor Pud, Dorit affil: Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston Massachusetts, U.S.A sug: subj: Attention Deficit Hyperactivity Disorder Pain Perception Methylphenidate Metabolism Pain Threshold Drug Effects Dopamine Metabolism Human Female Male Young Adult Adult Descriptive Statistics Data Analysis Software Wilcoxon Signed Rank Test Mann-Whitney U Test Log-Rank Test Spearman's Rank Correlation Coefficient Effect Size Cold Clinical Trials Adult: 19-44 years Female Male ab: Background Attention deficit hyperactivity disorder ( ADHD) is characterized by dysregulation of sensory processing and neurobiology of dopamine. Although cumulative evidence suggests that dopamine is involved in pain processing, pain perception in ADHD subjects and the effect of dopamine agonists such as methylphenidate ( MP, Ritalin) on it have rarely been studied. Aims The aims of this study were to (1) psychophysically assess sensitivity to pain in ADHD subjects as compared to controls and (2) examine the effects of MP on pain response in ADHD subjects. Methods Thirty subjects with ADHD and 30 age- and gender-matched controls participated in a preliminary trial. Pain threshold, intensity, and tolerance in response to cold pain stimulation were measured for both groups ( ADHD with no treatment). In addition, the ADHD group was reassessed following a single dose of MP treatment. Results The ADHD subjects 'without MP' in comparison with controls displayed significantly shorter cold pain threshold (2.8 ± 2.1 vs. 5.8 ± 2.5 seconds, respectively, P < 0.001) and cold tolerance (21.8 ± 22.3 vs. 62.8 ± 59.8 seconds, respectively P < 0.001). No differences in pain intensities between the groups were found. Following MP treatment, both cold threshold and tolerance in the ADHD subjects increased significantly compared to those with no treatment (3.6 ± 2.5 seconds, P = 0.011, and 46.4 ± 53.3 seconds, P < 0.001, respectively). Conclusions These results suggest that adults with ADHD are more sensitive to pain compared with controls and that MP may exert antinociceptive properties in these subjects. Randomized, controlled trials are warranted to verify these findings. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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