Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production.

We describe a 71-year-old man who presented with abdominal pain, lower-extremity edema, recent unintentional weight loss, hypertension, hyperglycemia, hypokalemia, and metabolic alkalosis. Serum cortisol levels remained elevated after overnight high-dose dexamethasone suppression. Magnetic resonance...

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Publicado en:Baylor University Medical Center Proceedings Vol. 28; no. 1; pp. 46 - 50
Autores principales: Vaduganathan, Muthiah, Nagarur, Amulya, Kerr, Darcy A., Lauter, Kelly B., Padmanabhan, Arun, Raghavan, Srivatsan, Pallais, Juan C., Fenves, Andrew Z.
Formato: case study diagnostic images pictorial tables/charts Journal Article
Publicado: Taylor & Francis Ltd Jan2015
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jan2015
      vid: 28
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/08998280.2015.11929184
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        atl: Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production.
      aug:
        au:
          Vaduganathan, Muthiah
          Nagarur, Amulya
          Kerr, Darcy A.
          Lauter, Kelly B.
          Padmanabhan, Arun
          Raghavan, Srivatsan
          Pallais, Juan C.
          Fenves, Andrew Z.
        affil: Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
      sug:
        subj:
          Neuroendocrine Tumors Diagnosis
          Pancreatic Neoplasms Diagnosis
          Neoplasm Metastasis Diagnosis
          Adrenocorticotropic Hormone
          Neuroendocrine Tumors Therapy
          Neuroendocrine Tumors Surgery
          Aged
          Male
          Abdominal Pain Etiology
          Edema Etiology
          Alkalosis Etiology
          Magnetic Resonance Imaging
          Biopsy
          Chemoembolization, Therapeutic
          Adrenalectomy
          Neuroendocrine Tumors Mortality
          Postoperative Complications
          Aged: 65+ years
          Male
      ab: We describe a 71-year-old man who presented with abdominal pain, lower-extremity edema, recent unintentional weight loss, hypertension, hyperglycemia, hypokalemia, and metabolic alkalosis. Serum cortisol levels remained elevated after overnight high-dose dexamethasone suppression. Magnetic resonance imaging revealed a small mass in the head of the pancreas with scattered liver metastases. Both endoscopic ultrasound-guided pancreatic biopsy and liver biopsy revealed a welldifferentiated neuroendocrine tumor. These lesions did not show significant uptake on octreotide scan. Medical management and hepatic artery chemoembolization were attempted. Ultimately, the patient underwent bilateral adrenalectomy, but died within 4 months of symptom onset secondary to postoperative complications.
      pubtype: Academic Journal
      doctype:
        case study
        diagnostic images
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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