Timing Is Everything: Unifying Codon Translation Rates and Nascent Proteome Behavior.
Experiments have demonstrated that changing the rate at which the ribosome translates a codon position in an mRNA molecule's open reading frame can alter the behavior of the newly synthesized protein. That is, codon translation rates can govern nascent proteome behavior. We emphasize that this pheno...
| Published in: | Journal of the American Chemical Society Vol. 136; no. 52; pp. 17892 - 17899 |
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| Main Authors: | , |
| Format: | Article |
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American Chemical Society
12/31/2014
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=100583449&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 100583449 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 12/31/2014 vid: 136 iid: 52 pid: 997 pub: American Chemical Society artinfo: ui: 100583449 10.1021/ja510082j ppf: 17892 ppct: 7 formats: tig: atl: Timing Is Everything: Unifying Codon Translation Rates and Nascent Proteome Behavior. aug: au: Nissley, Daniel A. O'Brien, Edward P. affil: Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States su: Genetic code Genetic translation Proteomics Messenger RNA Non-equilibrium reactions Chromosomal translocation Clustering of particles Proteins sug: subj: Genetic code Genetic translation Proteomics Messenger RNA Non-equilibrium reactions Chromosomal translocation Clustering of particles Proteins ab: Experiments have demonstrated that changing the rate at which the ribosome translates a codon position in an mRNA molecule's open reading frame can alter the behavior of the newly synthesized protein. That is, codon translation rates can govern nascent proteome behavior. We emphasize that this phenomenon is a manifestation of the nonequilibrium nature of cotranslational processes, and as such, there exist theoretical tools that offer a potential means to quantitatively predict the influence of codon translation rates on the broad spectrum of nascent protein behaviors including cotranslational folding, aggregation, and trans-location. We provide a review of the experimental evidence for the impact that codon translation rates can have, followed by a discussion of theoretical methods that can describe this phenomenon. The development and application of these tools are likely to provide fundamental insights into protein maturation and homeostasis, codon usage bias in organisms, the origins of translation related diseases, and new rational design methods for biotechnology and biopharmaceutical applications. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2014 holdings: @attributes: islocal: N |
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