Genetic Information in the Age of DNA Sequencing.
The claim that genes encode and transmit information is a central conceptual tenet in biomedicine. Historians have placed the origins of this claim in the rise of molecular biology after World War II, and philosophers still debate the utility of understanding genes as information for biomedical rese...
| Publicado en: | Information & Culture Vol. 50; no. 1; pp. 110 - 143 |
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| Formato: | Artículo |
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University of Texas Press
2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=100834069&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 100834069 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 21648034 FB2C jtl: Information & Culture issn: 21648034 maglogo: N pubinfo: dt: 2015 vid: 50 iid: 1 pid: 519 pub: University of Texas Press artinfo: ui: 100834069 10.1353/lac.2015.0000 ppf: 110 ppct: 33 formats: fmt: @attributes: type: P size: 12.6MB tig: atl: Genetic Information in the Age of DNA Sequencing. aug: au: García-Sancho, Miguel affil: Chancellor's Fellow, Department of Science, Technology and Innovation Studies of the University of Edinburgh su: Nucleotide sequencing DNA History of molecular biology Crick, Francis, 1916-2004 Brenner, Sydney, 1927-2019 Sanger, Frederick, 1918-2013 Encoding Knowledge transfer Twentieth century History sug: subj: Nucleotide sequencing DNA History of molecular biology Crick, Francis, 1916-2004 Brenner, Sydney, 1927-2019 Sanger, Frederick, 1918-2013 Encoding Knowledge transfer Twentieth century History ab: The claim that genes encode and transmit information is a central conceptual tenet in biomedicine. Historians have placed the origins of this claim in the rise of molecular biology after World War II, and philosophers still debate the utility of understanding genes as information for biomedical research. In this article, I will investigate how "genetic information" as both a concept and a model for experimental practice was affected by the emergence in the mid-1970s of technologies that enabled scientists to determine the sequence of chemical units of DNA, the molecule that constitutes genetic material. I argue that DNA sequencing, rather than changing the meaning of genetic information, transformed the possibilities of what could be achieved with this concept and directed it to large-scale enterprises such as the Human Genome Project. Thus, my argument suggests that scientific concepts should be regarded as entities that, beyond abstract thinking, enable researchers to do things--in this case, embarking on a multi-million-dollar project aimed at sequencing the information encoded in the human genome. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Information & Culture is the property of University of Texas Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Information & Culture holder: University of Texas Press dt: @attributes: year: 2015 holdings: @attributes: islocal: N |
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