Nano-Gold Corking and Enzymatic Uncorking of Carbon Nanotube Cups.
Because of their unique stacked, cup-shaped, hollow compartments, nitrogen-doped carbon nanotube cups (NCNCs) have promising potential as nanoscale containers. Individual NCNCs are isolated from their stacked structure through acid oxidation and subsequent probe-tip sonication. The NCNCs are then ef...
| Publicado en: | Journal of the American Chemical Society Vol. 137; no. 2; pp. 675 - 685 |
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| Autores principales: | , , , , , , , , |
| Formato: | Artículo |
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American Chemical Society
1/21/2015
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=101085178&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 101085178 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 1/21/2015 vid: 137 iid: 2 pid: 997 pub: American Chemical Society artinfo: ui: 101085178 10.1021/ja511843w ppf: 675 ppct: 10 formats: tig: atl: Nano-Gold Corking and Enzymatic Uncorking of Carbon Nanotube Cups. aug: au: Yong Zhao Burkert, Seth C. Yifan Tang Sorescu, Dan C. Kapralov, Alexandr A. Shurin, Galina V. Shurin, Michael R. Kagan, Valerian E. Star, Alexander affil: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States National Energy Technology Laboratory, U.S. Department of Energy, Pittsburgh, Pennsylvania 15263, United States Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, United States Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, United States su: Carbon nanotubes Nucleation Gold nanoparticles Raman microscopy Nanocapsules Density functional theory sug: subj: Carbon nanotubes Nucleation Gold nanoparticles Raman microscopy Nanocapsules Density functional theory ab: Because of their unique stacked, cup-shaped, hollow compartments, nitrogen-doped carbon nanotube cups (NCNCs) have promising potential as nanoscale containers. Individual NCNCs are isolated from their stacked structure through acid oxidation and subsequent probe-tip sonication. The NCNCs are then effectively corked with gold nanoparticles (GNPs) by sodium citrate reduction with chloroauric acid, forming graphitic nanocapsules with significant surface-enhanced Raman signature. Mechanistically, the growth of the GNP corks starts from the nucleation and welding of gold seeds on the open rims of NCNCs enriched with nitrogen functionalities, as confirmed by density functional theory calculations. A potent oxidizing enzyme of neutrophils, myeloperoxidase (MPO), can effectively open the corked NCNCs through GNP detachment, with subsequent complete enzymatic degradation of the graphitic shells. This controlled opening and degradation was further carried out in vitro with human neutrophils. Furthermore, the GNP-corked NCNCs were demonstrated to function as novel drug delivery carriers, capable of effective (i) delivery of paclitaxel to tumor-associated myeloid-derived suppressor cells (MDSC), (ii) MPO-regulated release, and (iii) blockade of MDSC immunosuppressive potential. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2015 holdings: @attributes: islocal: N |
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