Genetic Variability in CYP2E1 and Catalase Gene Among Currently and Formerly Alcohol-Dependent Male Subjects.
Aims: The present study explored whether specific single-nucleotide polymorphisms in alcohol metabolic pathway are associated with alcohol dependence or alcohol-related psychopathological symptoms. Methods: Three groups of male unrelated subjects were included: 101 currently alcohol-dependent patien...
| Published in: | Alcohol & Alcoholism Vol. 50; no. 2; pp. 140 - 146 |
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| Main Authors: | , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Oxford University Press / USA
Mar2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=101371651&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 101371651 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Mar2015 vid: 50 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 101371651 103765760 103765760 10.1093/alcalc/agu088 101371651 ppf: 140 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Genetic Variability in CYP2E1 and Catalase Gene Among Currently and Formerly Alcohol-Dependent Male Subjects. aug: au: Plemenitas, Anja Kastelic, Matej Porcelli, Stefano Serretti, Alessandro Rus Makovec, Maja Kores Plesnicar, Blanka Dolžan, Vita affil: Department of Psychiatry , University Clinical Center Maribor , Maribor , Slovenia sug: subj: Alcoholism Epidemiology Genetics Evaluation Polymorphism, Genetic Evaluation Funding Source Human Questionnaires Scales Psychological Tests Genotype Alleles Descriptive Statistics Odds Ratio Confidence Intervals P-Value Slovenia Male Adolescence Adult Middle Age Aged Chi Square Test Analysis of Variance Two-Tailed Test Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male ab: Aims: The present study explored whether specific single-nucleotide polymorphisms in alcohol metabolic pathway are associated with alcohol dependence or alcohol-related psychopathological symptoms. Methods: Three groups of male unrelated subjects were included: 101 currently alcohol-dependent patients, 100 formerly alcohol-dependent subjects and 97 healthy controls. The following questionnaires were implemented: AUDIT, Zung Depression and Anxiety scale, Brief Social Phobia Scale, Yale-Brown Obsessive Compulsive Scale, Obsessive Compulsive Drinking Scale and Buss-Durkee Hostility Inventory. All the subjects were genotyped for CYP2E1 c.-1053C>T and CAT c.-262C>T. Results: Statistically significant differences in the distribution of genotypes and alleles for CAT c.-262C>T polymorphism were observed among the three investigated groups. We observed a higher frequency of CAT -262T allele in alcohol-dependent subjects (OR = 1.74, 95% CI = 1.164–2.610). Among currently dependent patients CAT -262T allele carriers had higher AUDIT scores (P = 0.023), while CYP2E1-1053T allele carriers had significantly higher YBOCS-obsession subscale scores (P = 0.005) and Zung Anxiety Scale scores (P = 0.011). Conclusions: Our findings suggest that the CAT c.-262C>T genetic polymorphism influences the susceptibility to alcohol dependence and severity of alcohol dependence, while CYP2E1 c.-1053C>T polymorphism influences the expression of obsessive–compulsive and anxiety symptoms. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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