Pharmacotherapy and mortality in atrial fibrillation—a cohort of men and women 75 years or older in Sweden.
Background: atrial fibrillation (AF) is a common cardiovascular morbidity, not least among elderly people, and is treated with different classes of cardiovascular pharmacotherapies.Hypothesis: cardiovascular drugs may have a different impact on survival in elderly patients with AF in primary health...
| Published in: | Age & Ageing Vol. 44; no. 2; pp. 232 - 239 |
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| Main Authors: | , , , , , |
| Format: | Article |
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Oxford University Press / USA
Mar2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=101372220&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 101372220 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Mar2015 vid: 44 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 101372220 10.1093/ageing/afu153 ppf: 232 ppct: 7 formats: tig: atl: Pharmacotherapy and mortality in atrial fibrillation—a cohort of men and women 75 years or older in Sweden. aug: au: Wändell, Per Erik Carlsson, Axel Carl Sundquist, Jan Johansson, Sven-Erik Bottai, Matteo Sundquist, Kristina affil: Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge , Sweden Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala , Sweden Center for Primary Health Care Research , Lund University , Malmö , Sweden Stanford Prevention Research Center , Stanford University School of Medicine , CA , USA Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm , Sweden su: Sweden Mortality Therapeutics Therapeutic use of fibrinolytic agents Cardiovascular agents Atrial fibrillation Chi-squared test Confidence intervals Fisher exact test Regression analysis Research funding Survival T-test (Statistics) Proportional hazards models Data analysis software Descriptive statistics Disease complications sug: subj: Mortality Therapeutics Sweden Therapeutic use of fibrinolytic agents Cardiovascular agents Atrial fibrillation Chi-squared test Confidence intervals Fisher exact test Regression analysis Research funding Survival T-test (Statistics) Proportional hazards models Data analysis software Descriptive statistics Disease complications keyword: antithrombotic drugs mortality older people propensity score statins antithrombotic drugs mortality older people propensity score statins ab: Background: atrial fibrillation (AF) is a common cardiovascular morbidity, not least among elderly people, and is treated with different classes of cardiovascular pharmacotherapies.Hypothesis: cardiovascular drugs may have a different impact on survival in elderly patients with AF in primary health care.Methods: a cohort of 3,020 men and 3,749 women aged ≥75 and diagnosed with AF were selected from 75 primary care centres in Sweden. Laplace regression was used with years to death of the first 10% of the participants as the outcome. Independent variables were prescribed cardiovascular drugs. Regression models were adjusted for a propensity score comprising age, cardiovascular co-morbidities, socio-economic factors and other cardiovascular pharmacotherapies.Results: overall, mortality was 18.2%. The main finding of this study was survival increases associated with anticoagulants versus no treatment and versus antiplatelets of 1.95 years (95% confidence interval (CI) 1.43–2.48) and 0.78 years (95% CI 0.38–1.18), respectively, and survival increases associated with thiazides and calcium channel blockers of 0.81 years (95% CI 0.43–1.18) and 0.83 years (95% CI 0.47–1.18), respectively, in men and women together (results from sex-adjusted models).Conclusion: our findings suggest that anticoagulants, thiazides and calcium channel blockers may lead to longer survival in elderly patients with AF. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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