QUANTIFYING NICOTINE'S VALUE-ENHANCEMENT EFFECT USING A BEHAVIORAL ECONOMIC APPROACH.

Nicotine increases the value of some reinforcing stimuli, and this effect may contribute to nicotine's widespread abuse. We aimed to quantify this effect using a behavioral economic analysis. Six Long- Evans rats were exposed to a modified observing response procedure. In this procedure, presses to...

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Published in:Journal of the Experimental Analysis of Behavior Vol. 102; no. 3; pp. 353 - 363
Main Authors: Cassidy, Rachel N., Dallery, Jesse
Format: Article
Published: Wiley-Blackwell Nov2014
Subjects:
Online Access:View this record in EBSCOhost
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      dt: Nov2014
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      pub: Wiley-Blackwell
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        102181671
        10.1002/jeab.109
      ppf: 353
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        atl: QUANTIFYING NICOTINE'S VALUE-ENHANCEMENT EFFECT USING A BEHAVIORAL ECONOMIC APPROACH.
      aug:
        au:
          Cassidy, Rachel N.
          Dallery, Jesse
        affil:
          Brown University
          University of Florida
      su:
        Nicotine
        Behavioral economics
        Laboratory rats
        Demand function
        Stimulus & response (Psychology)
      sug:
        subj:
          Medicinal and Botanical Manufacturing
          All Other Animal Production
          Nicotine
          Behavioral economics
          Laboratory rats
          Demand function
          Stimulus & response (Psychology)
      keyword:
        behavioral economics
        behavioral pharmacology
        conditioned reinforcement
        nicotine
        rat
        behavioral economics
        behavioral pharmacology
        conditioned reinforcement
        nicotine
        rat
      ab: Nicotine increases the value of some reinforcing stimuli, and this effect may contribute to nicotine's widespread abuse. We aimed to quantify this effect using a behavioral economic analysis. Six Long- Evans rats were exposed to a modified observing response procedure. In this procedure, presses to one lever resulted either in food according to a variable-interval 15 s schedule or extinction; presses to a second, observing lever illuminated stimuli correlated with the schedule in effect on the food/extinction lever (i.e., conditioned reinforcers). The FR requirement on the observing lever increased across sessions. The number of presentations of the conditioned reinforcers was plotted as a function of FR value to generate a demand curve. Nicotine was then administered at a dose of 0.3 mg/kg. All demand curves were fitted to the exponential demand equation and a parameter reflecting reinforcer value was evaluated. Nicotine increased the value of the conditioned reinforcers as measured by this equation; nicotine also increased responding on the food/extinction lever. This analysis demonstrates that nicotine increases the value of conditioned reinforcers under certain conditions. The current procedure allows for a novel method of analyzing demand for conditioned reinforcers.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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