Anomalous White Matter Morphology in Adults Who Stutter.
Aims: Developmental stuttering is now generally considered to arise from genetic determinants interacting with neurologic function. Changes within speech-motor white matter (WM) connections may also be implicated. These connections can now be studied in great detail by high-angular-resolution diffus...
| Publicado en: | Journal of Speech, Language & Hearing Research Vol. 58; no. 2; pp. 268 - 278 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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American Speech-Language-Hearing Association
Apr2015
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=102472626&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 102472626 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10924388 1SM jtl: Journal of Speech, Language & Hearing Research issn: 10924388 maglogo: N pubinfo: dt: Apr2015 vid: 58 iid: 2 pid: 42 pub: American Speech-Language-Hearing Association artinfo: ui: 102472626 10.1044/2015_JSLHR-S-14-0193 ppf: 268 ppct: 10 formats: fmt: @attributes: type: P size: 989KB tig: atl: Anomalous White Matter Morphology in Adults Who Stutter. aug: au: Cieslak, Matthew Ingham, Roger J. Ingham, Janis C. Grafton, Scott T. affil: University of California, Santa Barbara su: California Developmental disabilities Graduate students Undergraduates Adults Morphology White matter (Nerve tissue) Physiological aspects of speech Neurology Brain Experimental design Magnetic resonance imaging Research funding Stuttering sug: subj: Developmental disabilities Graduate students Undergraduates Adults California Diagnostic Imaging Centers Morphology White matter (Nerve tissue) Physiological aspects of speech Neurology Brain Experimental design Magnetic resonance imaging Research funding Stuttering ab: Aims: Developmental stuttering is now generally considered to arise from genetic determinants interacting with neurologic function. Changes within speech-motor white matter (WM) connections may also be implicated. These connections can now be studied in great detail by high-angular-resolution diffusion magnetic resonance imaging. Therefore, diffusion spectrum imaging was used to reconstruct streamlines to examine white matter connections in people who stutter (PWS) and in people who do not stutter (PWNS). Method: WM morphology of the entire brain was assayed in 8 right-handed male PWS and 8 similarly aged right-handed male PWNS. WM was exhaustively searched using a deterministic algorithm that identifies missing or largely misshapen tracts. To be abnormal, a tract (defined as all streamlines connecting a pair of gray matter regions) was required to be at least one 3rd missing, in 7 out of 8 subjects in one group and not in the other group. Results: Large portions of bilateral arcuate fasciculi, a heavily researched speech pathway, were abnormal in PWS. Conversely, all PWS had a prominent connection in the left temporo-striatal tract connecting frontal and temporal cortex that was not observed in PWNS. Conclusion: These previously unseen structural differences of WM morphology in classical speech-language circuits may underlie developmental stuttering. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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