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Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins.

Methods to site-specifically and densely label proteins in cellular ultrastructures with small, bright, and photostable fluorophores would substantially advance super-resolution imaging. Recent advances in genetic code expansion and bioorthogonal chemistry have enabled the site-specific labeling of...

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Published in:Journal of the American Chemical Society Vol. 137; no. 14; pp. 4602 - 4606
Main Authors: Uttamapinant, Chayasith, Howe, Jonathan D., Lang, Kathrin, Beránek, Václav, Davis, Lloyd, Mahesh, Mohan, Barry, Nicholas P., Chin, Jason W.
Format: Article
Published: American Chemical Society 4/15/2015
Subjects:
Genetic code
Proteins
Fluorophores
High resolution imaging
Amino acids
Online Access:View this record in EBSCOhost