Therapeutic antibodies for improved wound healing.
Therapeutic monoclonal antibodies (mAbs) are the fastest growing area of drug development, with an increasing number of diseases, including rheumatoid arthritis, multiple sclerosis and various forms of cancer, now amenable to treatment. Therapeutic mAbs bind to proteins or cells that are involved in...
| Publicado en: | Wound Practice & Research Vol. 23; no. 1; pp. 16 - 25 |
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| Autores principales: | , , |
| Formato: | pictorial review Journal Article |
| Publicado: |
Cambridge Publishing
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=102774195&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 102774195 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18376304 639G jtl: Wound Practice & Research issn: 18376304 maglogo: N pubinfo: dt: Mar2015 vid: 23 iid: 1 pid: 66266 pub: Cambridge Publishing artinfo: ui: 102774195 102774195 109787400 102774195 ppf: 16 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Therapeutic antibodies for improved wound healing. aug: au: Turner, Christopher T. McInnes, Steven J. P. Cowin, Allison J. affil: University of South Australia, Mawson Institute, Regenerative Medicine, SA, Australia sug: subj: Antibodies, Monoclonal Therapeutic Use Antibodies, Monoclonal Physiology Cytokines Physiology Cytokines Metabolism Wound Healing Physiology Wounds and Injuries Drug Therapy Wounds and Injuries Physiopathology Wounds, Chronic Drug Therapy Wounds, Chronic Physiopathology Inflammation Physiopathology Antibodies, Monoclonal Pharmacodynamics Antibodies, Monoclonal Metabolism Antibodies, Monoclonal Administration and Dosage Acute Disease Models, Biological Animal Studies Cytotoxins Metabolism Cicatrix Physiology Cicatrix Prevention and Control Matrix Metalloproteinases Physiology Drug Design Cell Death Growth Substances Metabolism Tumor Necrosis Factor Metabolism Interleukins Metabolism Tumor Necrosis Factor Physiology ab: Therapeutic monoclonal antibodies (mAbs) are the fastest growing area of drug development, with an increasing number of diseases, including rheumatoid arthritis, multiple sclerosis and various forms of cancer, now amenable to treatment. Therapeutic mAbs bind to proteins or cells that are involved in the development of disease, impairing their ability to further contribute to the pathology. Currently, the treatment of acute and chronic wounds is an area of unmet clinical need. There are a number of proteins and cell types that are detrimental to wound healing and are up-regulated in the wound environment, especially in chronic wounds, with a reduction expected to improve healing outcomes. Therapeutic mAbs may therefore potentially provide a valuable new tool for wound treatment. This review explores the application of mAb therapies in wound healing. pubtype: Academic Journal doctype: pictorial review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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