Increasing biopsy number and sampling from gastric body improve the sensitivity of rapid urease test in patients with peptic ulcer bleeding.
Background: Previous studies demonstrated that the sensitivity of rapid urease test (RUT) for diagnosis of Helicobacter pylori infection decreased during peptic ulcer bleeding.Aim: We designed this study and tried to find a better method to improve the detection rate of H. pylori infection at the sa...
| Publicado en: | Digestive Diseases & Sciences Vol. 60; no. 2; pp. 454 - 458 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103746389&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103746389 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01632116 1VP jtl: Digestive Diseases & Sciences issn: 01632116 maglogo: N pubinfo: dt: Feb2015 vid: 60 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103746389 NLM25213078 2012885242 10.1007/s10620-014-3351-8 NLM25213078 103746389 ppf: 454 ppct: 4 formats: tig: atl: Increasing biopsy number and sampling from gastric body improve the sensitivity of rapid urease test in patients with peptic ulcer bleeding. aug: au: Lee, Tzong-Hsi Lin, Chien-Chu Chung, Chen-Shuan Lin, Cheng-Kuan Liang, Cheng-Chao Tsai, Kuang-Chau affil: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Far Eastern Memorial Hospital, 21, Sec. 2, Nan-Ya South Road, Banciao District, New Taipei City, 22060, Taiwan, thleekimo@yahoo.com.tw. sug: subj: Bacterial Proteins Metabolism Biopsy Methods Breath Tests Duodenal Ulcer Diagnosis Helicobacter Infections Diagnosis Helicobacter Pylori Peptic Ulcer Diagnosis Urease Metabolism Aged Gastrointestinal Agents Therapeutic Use Biological Markers Metabolism Carbon Dioxide Metabolism Isotopes Diagnostic Use Duodenal Ulcer Drug Therapy Duodenal Ulcer Microbiology Duodenal Ulcer Pathology Endoscopy, Gastrointestinal Female Helicobacter Infections Complications Helicobacter Infections Microbiology Helicobacter Infections Pathology Human Male Middle Age Peptic Ulcer Drug Therapy Peptic Ulcer Microbiology Peptic Ulcer Pathology Predictive Value of Tests Prospective Studies Proton Pump Inhibitors Therapeutic Use Risk Factors Time Factors Urea Diagnostic Use Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Background: Previous studies demonstrated that the sensitivity of rapid urease test (RUT) for diagnosis of Helicobacter pylori infection decreased during peptic ulcer bleeding.Aim: We designed this study and tried to find a better method to improve the detection rate of H. pylori infection at the same session of endoscopic diagnosis of peptic ulcer bleeding.Methods: We prospectively enrolled 116 patients with peptic ulcer bleeding. These patients received intravenous proton pump inhibitor and then received upper gastrointestinal endoscopy within 24 h after arrival. We took one piece of biopsy from gastric antrum (Group 1), four pieces from gastric antrum (Group 2), and one piece from the gastric body (Group 3) for three separate RUTs, respectively. (13)C-urease breath test was used as gold standard for diagnosis of H. pylori infection.Results: There were 74 patients (64 %) with positive (13)C-urease breath test. Among these 74 patients, 45 patients had positive RUT (sensitivity: 61 %) in Group 1; 55 patients had positive RUT (sensitivity: 74 %) in Group 2; 54 patients had positive RUT (sensitivity: 73 %) in Group 3. There were significant differences between Group 1 and Group 2 (p = 0.02) and between Group 1 and Group 3 (p = 0.022).Conclusions: The sensitivity of RUT was 61 % during peptic ulcer bleeding. The sensitivity of RUT can be increased significantly by increased biopsy number from gastric antrum or biopsy from gastric body. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|