Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous.
Heterogeneity is an inherent event to tumour development that is lately receiving much attention in oncologic research. The topic is being addressed primarily at the molecular level, and results are promising. However, translation to practical medicine is still pending. Our intention in this study i...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 466; no. 1; pp. 61 - 67 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103748087&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103748087 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Jan2015 vid: 466 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103748087 NLM25369891 2012893778 10.1007/s00428-014-1673-8 NLM25369891 103748087 ppf: 61 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous. aug: au: Zaldumbide, Laura Erramuzpe, Asier Guarch, Rosa Cortés, Jesús M López, José I affil: Department of Pathology, Cruces University Hospital, University of the Basque Country (UPV/EHU), Barakaldo, Bizkaia, Spain. sug: subj: Carcinoma, Renal Cell Metabolism Carcinoma, Renal Cell Pathology Oxidoreductases Metabolism Tumor Markers, Biological Metabolism Kidney Neoplasms Metabolism Kidney Neoplasms Pathology Body Weights and Measures Antigens, Tumor Metabolism Carbonic Anhydrases Metabolism Carcinoma, Renal Cell Diagnosis Cell Physiology Female Genes Human Kidney Neoplasms Diagnosis Male Neoplasm Grading Prognosis Prospective Studies Proteins Metabolism Esterases Metabolism Female Male ab: Heterogeneity is an inherent event to tumour development that is lately receiving much attention in oncologic research. The topic is being addressed primarily at the molecular level, and results are promising. However, translation to practical medicine is still pending. Our intention in this study is to approach the problem in a series of clear cell renal cell carcinomas with the tools that pathologists use in routine practice. Three randomly selected areas of 48 clear cell renal cell carcinomas prospectively collected in two different institutions were analysed for intratumour heterogeneity. The evaluated parameters were tumour size, cell type (clear vs. eosinophilic), Fuhrman's grade and immunohistochemical expression of carbonic anhydrase IX, BRCA1-associated protein-1 (BAP-1), cyclooxygenase-2 (COX-2) and Ki67. Intratumour heterogeneity was detected in 26 cases (54 %). Cell type, grade and Ki67 index were the parameters more frequently heterogeneous amounting, respectively, 44, 42 and 38 %. Tumour size was a significantly discriminative factor to predict tumour heterogeneity, with a cut-off of 3.8 cm (p < 0.001). Aside from tumour size, the most relevant parameters related with intratumour heterogeneity were cell type (clear vs. eosinophilic), Fuhrman's grade and Ki67 and COX-2 expression patterns. Carbonic anhydrase 9 and BAP-1 did not show statistical relevance. We conclude that heterogeneity is a common event in clear cell renal cell carcinomas that may be overlooked in cases insufficiently sampled. Tumour size appears as a reliable tool in identifying this situation since clear cell renal cell carcinomas under 3.8 cm in diameter are always homogeneous. This point may help the pathologist to make decisions in tumour sampling. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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