Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders.
Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of osc...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 45; no. 2; pp. 395 - 406 |
|---|---|
| Autores principales: | , , , , , , , , , , , , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103751312&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103751312 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Feb2015 vid: 45 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103751312 100695447 10.1007/s10803-013-1904-x NLM23963591 103751312 ppf: 395 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Neuromagnetic Oscillations Predict Evoked-Response Latency Delays and Core Language Deficits in Autism Spectrum Disorders. aug: au: Edgar, J. Khan, Sarah Blaskey, Lisa Chow, Vivian Rey, Michael Gaetz, William Cannon, Katelyn Monroe, Justin Cornew, Lauren Qasmieh, Saba Liu, Song Welsh, John Levy, Susan Roberts, Timothy affil: Department of Radiology, Lurie Family Foundations MEG Imaging Center, The Children's Hospital of Philadelphia, Wood Bldg, Suite 2115, 34th St. and Civic Center Blvd Philadelphia 19104 USA sug: subj: Evoked Potentials, Auditory Autism Spectrum Disorder Symptoms Time Factors Evaluation Language Disorders Symptoms Human Funding Source Electroencephalography Electromagnetic Fields Methods Language Tests Auditory Cortex Physiopathology Pretest-Posttest Design Male Female Child T-Tests Questionnaires Scales Electroencephalography Methods Data Analysis Software Cluster Analysis Analytic Research Child: 6-12 years Male Female ab: Previous studies have observed evoked response latency as well as gamma band superior temporal gyrus (STG) auditory abnormalities in individuals with autism spectrum disorders (ASD). A limitation of these studies is that associations between these two abnormalities, as well as the full extent of oscillatory phenomena in ASD in terms of frequency and time, have not been examined. Subjects were presented pure tones at 200, 300, 500, and 1,000 Hz while magnetoencephalography assessed activity in STG auditory areas in a sample of 105 children with ASD and 36 typically developing controls (TD). Findings revealed a profile such that auditory STG processes in ASD were characterized by pre-stimulus abnormalities across multiple frequencies, then early high-frequency abnormalities followed by low-frequency abnormalities. Increased pre-stimulus activity was a 'core' abnormality, with pre-stimulus activity predicting post-stimulus neural abnormalities, group membership, and clinical symptoms (CELF-4 Core Language Index). Deficits in synaptic integration in the auditory cortex are associated with oscillatory abnormalities in ASD as well as patient symptoms. Increased pre-stimulus activity in ASD likely demonstrates a fundamental signal-to-noise deficit in individuals with ASD, with elevations in oscillatory activity suggesting an inability to maintain an appropriate 'neural tone' and an inability to rapidly return to a resting state prior to the next stimulus. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|