Renal interstitial mast cell counts differ across classes of proliferative lupus nephritis.
Systemic lupus erythematosus frequently involves the kidneys leading to significant morbidity and mortality. It is classified according to glomerular involvement pattern but tubulointerstitial lesions are also important for progression and prognosis, as seen in other kidney glomerular diseases. One...
| Publicado en: | Folia Histochemica et Cytobiologica Vol. 52; no. 3; pp. 218 - 225 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
VM Medica-VM Group (Via Medica)
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103753271&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103753271 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02398508 3GX0 jtl: Folia Histochemica et Cytobiologica issn: 02398508 maglogo: N pubinfo: dt: 2014 vid: 52 iid: 3 pid: 21698 pub: VM Medica-VM Group (Via Medica) artinfo: ui: 103753271 98902491 10.5603/FHC.2014.0025 103753271 ppf: 218 ppct: 7 formats: tig: atl: Renal interstitial mast cell counts differ across classes of proliferative lupus nephritis. aug: au: Kaczmarczyk, Karolina Kosalka, Joanna Soja, Jerzy Kuzniewski, Marek Musial, Jacek Okon, Krzysztof affil: Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Cracow, Poland sug: subj: Mast Cells Analysis Lupus Nephritis Classification Nephritis, Interstitial Human In Vitro Studies Male Female Histological Techniques Adult Middle Age Descriptive Statistics Data Analysis Software Kruskal-Wallis Test Mann-Whitney U Test Analysis of Variance Spearman's Rank Correlation Coefficient Post Hoc Analysis Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Systemic lupus erythematosus frequently involves the kidneys leading to significant morbidity and mortality. It is classified according to glomerular involvement pattern but tubulointerstitial lesions are also important for progression and prognosis, as seen in other kidney glomerular diseases. One of the cell types which participate in this process are mast cells. The aim of the study was to analyze the counts of tryptase-positive and chymase-positive mast cells in lupus nephritis classes II, III and IV. Material consisted of 42 renal biopsies from patients with lupus nephritis; 11 class II, 9 class III and 22 class IV. Chymase- and tryptase-containing cells were stained by immunohistochemistry and counted microscopically. Mean count of chymase-positive mast cells was 9.8/10 high power fields (hpf) for the whole group, 4.66 for class II, 11.89 for class III, and 11.51 for class IV. The mean count of tryptase-positive cells was 18.6/10 hpf for the whole group, 7.65 for class II, 25.57 for class III, and 21.23 for class IV. The differences between lupus nephritis classes were significant both for chymase- and tryptase-positive cells. Tryptase- but not chymase-positive cell counts showed a correlation with the creatinine level (R = 0.35). These results suggest that mast cells are involved to a different degree in the pathogenesis of lupus nephritis depending on the class of the disease. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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