Relation of Epicardial Fat Thickness to Subclinical Right Ventricular Dysfunction Assessed by Strain and Strain Rate Imaging in Subjects with Metabolic Syndrome: A Two-Dimensional Speckle Tracking Echocardiography Study.
Background Right ventricular ( RV) function is known to be impaired in the presence of metabolic syndrome (MetS). Epicardial adipose tissue is a metabolically active organ that generates various bioactive molecules, which might affect cardiac function and morphology. Thus, we hypothesized that RV dy...
| Publicado en: | Echocardiography Vol. 32; no. 2; pp. 248 - 257 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103754890&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103754890 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Feb2015 vid: 32 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103754890 100952665 10.1111/echo.12635 NLM24815416 103754890 ppf: 248 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Relation of Epicardial Fat Thickness to Subclinical Right Ventricular Dysfunction Assessed by Strain and Strain Rate Imaging in Subjects with Metabolic Syndrome: A Two-Dimensional Speckle Tracking Echocardiography Study. aug: au: Gökdeniz, Tayyar Erkol, Ayhan Kalaycıoğlu, Ezgi Çağrı Aykan, Ahmet Gül, İlker Boyacı, Faruk Turan, Burak Ozkan, Mehmet affil: Department of Cardiology, Kafkas University Medical School sug: subj: Echocardiography Metabolic Diseases In Middle Age Ventricular Dysfunction, Right Human Nonparametric Statistics Probability Sample Data Analysis Software T-Tests Mann-Whitney U Test Chi Square Test Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient P-Value Adipose Tissue Ventricular Dysfunction, Left Male Female Ventricular Function, Right Univariate Statistics Comorbidity Linear Regression Middle Age Middle Aged: 45-64 years Male Female ab: Background Right ventricular ( RV) function is known to be impaired in the presence of metabolic syndrome (MetS). Epicardial adipose tissue is a metabolically active organ that generates various bioactive molecules, which might affect cardiac function and morphology. Thus, we hypothesized that RV dysfunction in patients with MetS may be related to increased epicardial fat thickness ( EFT) in these patients. In patients with MetS, we aimed to assess the relation of EFT with RV function using two-dimensional speckle tracking echocardiography (2D STE)-derived strain and strain rate imaging. Methods The study involved 76 subjects with MetS and 61 subjects without MetS. Biventricular structure and function together with EFT were evaluated by conventional echocardiography. RV free and septal walls strain ( RVFW-S & RVSW-S), systolic and early diastolic strain rates ( RVSRs & RVSRe) were evaluated by 2D STE. Results Epicardial fat thickness was significantly higher in subjects with MetS (6.45 ± 1.48 mm vs. 5.49 ± 1.05 mm, P < 0.001). RVFW-S (−22.95 ± 4.97% vs. −24.96 ± 3.63%; P = 0.007), RVSRs (1.53 ± 0.33/sec vs. −1.70 ± 0.33/sec; P = 0.002), and RVSRe (1.40 ± 0.44/sec vs. 1.75 ± 0.49/sec; P < 0.001) were all lower in subjects with MetS, while RVSW-S did not differ. Multiple regression analysis showed that EFT was independently associated with RVFW-S ( β = −0.547, P < 0.001), RVSRs ( β = −0.332, P = 0.001), and RVSRe ( β = −0.187, P = 0.019) in subjects with MetS. Conclusions Metabolic syndrome is associated with subclinical RV systolic and diastolic dysfunction. In subjects with MetS, increased EFT is independently related to RV systolic and diastolic dysfunction. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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