Impact of Asymptomatic Acute Cellular Rejection on Left Ventricle Myocardial Function Evaluated by Means of Two-Dimensional Speckle Tracking Echocardiography in Heart Transplant Recipients.
Background Our objective was to evaluate the impact of asymptomatic acute cellular rejection ( ACR) in left ventricular myocardial strain in heart transplant ( HT) recipients by means of two-dimensional speckle tracking echocardiography (2 DSTE). Methods From September 1, 2009 to December 15, 2010 a...
| Publicado en: | Echocardiography Vol. 32; no. 2; pp. 229 - 238 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103754908&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103754908 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07422822 GSE jtl: Echocardiography issn: 07422822 maglogo: Y pubinfo: dt: Feb2015 vid: 32 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103754908 100952684 10.1111/echo.12623 NLM24814366 103754908 ppf: 229 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Impact of Asymptomatic Acute Cellular Rejection on Left Ventricle Myocardial Function Evaluated by Means of Two-Dimensional Speckle Tracking Echocardiography in Heart Transplant Recipients. aug: au: Ruiz Ortiz, Martín Peña, María Luisa Mesa, Dolores Delgado, Mónica Romo, Elías Santisteban, Marta Puentes, Miguel López Granados, Amador Castillo, Juan Carlos Arizón, José María Lezo, José Suárez affil: Cardiology Department, Reina Sofía University Hospital sug: subj: Heart Transplantation Graft Rejection Evaluation Heart Ventricle, Left Physiopathology Myocardial Diseases Echocardiography Methods Descriptive Statistics Human Random Sample Interrater Reliability One-Way Analysis of Variance T-Tests Mann-Whitney U Test Logistic Regression ROC Curve Data Analysis Software Female Male Middle Age Aged Adult Odds Ratio Confidence Intervals Intrarater Reliability Middle Aged: 45-64 years Aged: 65+ years Adult: 19-44 years Female Male ab: Background Our objective was to evaluate the impact of asymptomatic acute cellular rejection ( ACR) in left ventricular myocardial strain in heart transplant ( HT) recipients by means of two-dimensional speckle tracking echocardiography (2 DSTE). Methods From September 1, 2009 to December 15, 2010 a conventional echocardiography and 2 DSTE exam was performed on all consecutive HT recipients in their first year posttransplantation within 3 hours of the surveillance endomyocardial biopsies, as well as on 14 healthy controls. The association of strain echocardiographic variables with different grades of ACR was investigated. Results Of the 78 studies performed 4 ± 3 months after HT in 20 patients, 32 studies were coincident with grade 0R rejection, 41 with grade 1R, and 5 with grade 2R. Significantly lower values of average radial strain were found with higher grades of ACR (29.1 ± 7.7%, 23.2 ± 8.5%, and 14.3 ± 8.8% for grades 0R, 1R, and 2R of ACR, P = 0.001). Average deformation was similar for controls versus transplanted patients, in the absence of acute rejection: radial 29.1 ± 10.0% versus 29.1 ± 7.7%, P = 0.98; circumferential −19.3 ± 3.2% versus −20.2 ± 5.9%, P = 0.62; and longitudinal −20.7 ± 4.1% versus −18.5 ± 5.4%, P = 0.19. An average radial strain <25% presented 100% sensitivity, 48% specificity, 6% positive predictive value, and 100% negative predictive value for the presence of 2R rejection (area under the curve 0.80, IC 95% 0.60-0.99, P = 0.048). Conclusion In this study, HT recipients showed significantly lower values of average radial left ventricle strain, evaluated by means of 2 DSTE, with the presence of ACR. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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