Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume.
Alpha circuits (8-12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Give...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 45; no. 3; pp. 795 - 805 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103763371&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103763371 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Mar2015 vid: 45 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103763371 101133120 10.1007/s10803-014-2236-1 NLM25231288 103763371 ppf: 795 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume. aug: au: Edgar, J. Heiken, Kory Chen, Yu-Han Herrington, John Chow, Vivian Liu, Song Bloy, Luke Huang, Mingxiong Pandey, Juhi Cannon, Katelyn Qasmieh, Saba Levy, Susan Schultz, Robert Roberts, Timothy affil: Lurie Family Foundations MEG Imaging Center, Department of Radiology, The Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Wood Building, Suite 2115 Philadelphia 10104 USA sug: subj: Autism Spectrum Disorder Symptoms Autism Spectrum Disorder Radiography Brain Mapping Thalamus Physiopathology Human Funding Source Thalamus Radiography Child Scales Evoked Potentials, Somatosensory Replication Studies Male Adolescence Questionnaires Interview Guides Interviews Radiography Equipment and Supplies Electroencephalography T-Tests Child: 6-12 years Adolescent: 13-18 years Male ab: Alpha circuits (8-12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha rhythms, associations between thalamic structure and alpha activity were examined. RS magnetoencephalography was obtained from 47 typically-developing children (TDC) and 41 children with ASD. RS alpha activity was measured using distributed source localization. Left and right thalamic volume measurements were also obtained. In both groups, the strongest alpha activity was observed in Calcarine Sulcus regions. In Calcarine regions, only TDC showed the expected association between age and alpha peak frequency. ASD had more alpha activity than TDC in regions bordering the Central Sulcus as well as parietal association cortices. In ASD, whereas greater left Central Sulcus relative alpha activity was associated with higher Social Responsiveness Scale (SRS) scores, greater Calcarine region relative alpha activity was associated with lower SRS scores. Although thalamic volume group differences were not observed, relationships between thalamic volume and Calcarine alpha power were unique to TDC. The present study also identified a failure to shift peak alpha frequency as a function of age in primary alpha-generating areas in children with ASD. Findings suggested that increased RS alpha activity in primary motor and somatosensory as well as parietal multimodal areas-with increased alpha thought to reflect greater inhibition-might impair the ability to identify or interpret social cues. Finally, to our knowledge, this is the first study to report associations between thalamic volume and alpha power, an association observed only in TDC. The lack of thalamic and alpha associations in ASD suggests thalamic contributions to RS alpha abnormalities in ASD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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