Nasal Mucociliary Clearance in Subjects With COPD After Smoking Cessation.
BACKGROUND: Exposure to cigarette smoke causes significant impairment in mucociliary clearance (MCC), which predisposes patients to secretion retention and recurrent airway infections that play a role in exacerbations of COPD. To determine whether smoking cessation may influence MCC and frequency of...
| Publicado en: | Respiratory Care Vol. 60; no. 3; pp. 399 - 406 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103766953&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103766953 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Mar2015 vid: 60 iid: 3 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 103766953 101311525 10.4187/respcare.03266 103766953 ppf: 399 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Nasal Mucociliary Clearance in Subjects With COPD After Smoking Cessation. aug: au: Ito, Juliana T. Ramos, Dionei Lima, Fabiano F. Rodrigues, Fernanda M. M. Gomes, Paulo R. Moreira, Graciane L. Macchione, Mariangela Toledo, Alessandra C. Ramos, Ercy M. C. affil: Department of Physiotherapy, Universidade Estadual Paulista (UNESP), Presidente Prudente sug: subj: Smoking Cessation Evaluation Pulmonary Disease, Chronic Obstructive Disease Exacerbation Mucociliary Clearance Statistics and Numerical Data Human Kruskal-Wallis Test Control Group Clinical Assessment Tools Cross Sectional Studies Observational Methods Male Female Middle Age Aged Aged, 80 and Over Patient History Taking Descriptive Statistics Data Analysis Software Post Hoc Analysis Spearman's Rank Correlation Coefficient Funding Source Questionnaires Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: BACKGROUND: Exposure to cigarette smoke causes significant impairment in mucociliary clearance (MCC), which predisposes patients to secretion retention and recurrent airway infections that play a role in exacerbations of COPD. To determine whether smoking cessation may influence MCC and frequency of exacerbations, the following groups were evaluated: ex-smokers with COPD, smokers with COPD, current smokers with normal lung function, and nonsmokers with normal lung function. METHODS: Ninety-three subjects were divided into 4 groups: ex-smokers with COPD (n = 23, 62.4 ± 8.0 y, 13 males), smokers with COPD (n = 17, 58.2 ± 8.0 y, 6 males), current smokers (n = 27, 61.5 ± 6.4 y, 17 males), and nonsmokers (n = 26, 60.8 ± 11.3 y, 7 males). MCC was evaluated using the saccharin transit time (STT) test, and the frequency of exacerbations in the last year was assessed by questionnaire. The Kruskal-Wallis test followed by Dunn’s test were used to compare STT among groups, and the Goodman test was used to compare the frequency of exacerbations. RESULTS: STT of smokers with COPD (16.5 [11–28] min; median [interquartile range 25–75%]) and current smokers (15.9 [10 –27] min) was longer compared with ex-smokers with COPD (9.7 [6 –12] min) and nonsmokers (8 [6 –16] min) (P < .001). There was no difference in STT values between smokers with COPD and current smokers, and these values in ex-smokers with COPD were similar to the control group (P > .05). The frequency of exacerbations was lower in ex-smokers with COPD compared with smokers with COPD. CONCLUSIONS: One year after smoking cessation, subjects with COPD had improved mucociliary clearance. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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