Characterization of Somatosensory Profiles in Patients with Crohn's Disease.
Background Crohn's disease ( CD) is a painful chronic inflammatory bowel disease. It primarily affects terminal ileum, but the involvement of large and small intestines or extraintestinal manifestations is very common. CD may go along with neurogenic inflammation, mediated by substance P and CGRP, w...
| Publicado en: | Pain Practice Vol. 15; no. 3; pp. 265 - 272 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103770444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103770444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307085 HYN jtl: Pain Practice issn: 15307085 maglogo: Y pubinfo: dt: Mar2015 vid: 15 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103770444 101423019 10.1111/papr.12182 NLM25597809 103770444 ppf: 265 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Characterization of Somatosensory Profiles in Patients with Crohn's Disease. aug: au: Münster, Tino Eckl, Stefanie Leis, Stefan Göhring-Waldeck, Gabriele Ihmsen, Harald Maihöfner, Christian affil: Department of Anesthesiology, Friedrich-Alexander Universität Erlangen-Nuremberg sug: subj: Crohn Disease Complications Somatosensory Disorders Symptoms Academic Medical Centers Germany Human Male Female Adolescence Adult Middle Age Aged Descriptive Statistics T-Tests Mann-Whitney U Test Chi Square Test Parametric Statistics Prospective Studies Cluster Analysis Models, Statistical Data Analysis Software Crohn Disease Classification Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background Crohn's disease ( CD) is a painful chronic inflammatory bowel disease. It primarily affects terminal ileum, but the involvement of large and small intestines or extraintestinal manifestations is very common. CD may go along with neurogenic inflammation, mediated by substance P and CGRP, which are also key players in pain transmission. This may in turn contribute to hyperalgesia and altered somatosensory function in CD. Methods One hundred and three (103) patients with CD and 80 healthy volunteers were enrolled. Patient characteristics and disease history were documented. We used quantitative sensory testing ( QST) to investigate the somatosensory profile in patients and volunteers. We also calculated z-scores for the QST results of the patients with CD based on the data of our control group. A 2-step cluster analysis, using all QST data, was performed to find subgroups within patients and volunteers. Results Thresholds of warm detection, mechanical pain, and vibration detection did significantly differ between patients with CD and volunteers. Z-scores indicated a general trend of sensory loss in CD patients with a significant relationship between patients with a sensory loss for cold and warm detection. In the hyposensitive cluster of the CD cohort, patients were more frequently male, had a higher incidence of extraintestinal manifestations, and suffered longer from CD. Conclusions Our findings are consistent with the presence of a subclinical small fiber neuropathy. The group of CD patients with pronounced neuropathy findings were predominantly males, had a higher incidence of extraintestinal manifestations, and tended to have a longer history of disease duration. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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