Classification of Hypervascular Liver Lesions Based on Hepatic Artery and Portal Vein Blood Supply Coefficients Calculated from Triphasic CT Scans.
Perfusion CT of the liver typically involves scanning the liver at least 20 times, resulting in a large radiation dose. We developed and validated a simplified model of tumor blood supply that can be applied to standard triphasic scans and evaluated whether this can be used to distinguish benign and...
| Publicado en: | Journal of Digital Imaging Vol. 28; no. 2; pp. 213 - 224 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103774879&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103774879 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08971889 DOQ jtl: Journal of Digital Imaging issn: 08971889 maglogo: N pubinfo: dt: Apr2015 vid: 28 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103774879 101556445 10.1007/s10278-014-9725-9 NLM25183580 PMC4359206 103774879 ppf: 213 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Classification of Hypervascular Liver Lesions Based on Hepatic Artery and Portal Vein Blood Supply Coefficients Calculated from Triphasic CT Scans. aug: au: Boas, F. Kamaya, Aya Do, Bao Desser, Terry Beaulieu, Christopher Vasanawala, Shreyas Hwang, Gloria Sze, Daniel affil: Interventional Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave New York 10065 USA sug: subj: Liver Blood Supply Hepatic Artery Portal Vein Liver Diseases Diagnosis Carcinoma, Hepatocellular Diagnosis Tomography, Emission-Computed Diagnosis, Differential Liver Diseases Classification Models, Theoretical Retrospective Design Descriptive Statistics P-Value Sensitivity and Specificity Two-Tailed Test T-Tests Confidence Intervals Human ab: Perfusion CT of the liver typically involves scanning the liver at least 20 times, resulting in a large radiation dose. We developed and validated a simplified model of tumor blood supply that can be applied to standard triphasic scans and evaluated whether this can be used to distinguish benign and malignant liver lesions. Triphasic CTs of 46 malignant and 32 benign liver lesions were analyzed. For each phase, regions of interest were drawn in the arterially enhancing portion of each lesion, as well as the background liver, aorta, and portal vein. Hepatic artery and portal vein blood supply coefficients for each lesion were then calculated by expressing the enhancement curve of the lesion as a linear combination of the enhancement curves of the aorta and portal vein. Hepatocellular carcinoma (HCC) and hypervascular metastases, on average, both had increased hepatic artery coefficients compared to the background liver. Compared to HCC, benign lesions, on average, had either a greater hepatic artery coefficient (hemangioma) or a greater portal vein coefficient (focal nodular hyperplasia or transient hepatic attenuation difference). Hypervascularity with washout is a key diagnostic criterion for HCC, but it had a sensitivity of 72 % and specificity of 81 % for diagnosing malignancy in our diverse set of liver lesions. The sensitivity for malignancy was increased to 89 % by including enhancing lesions that were hypodense on all phases. The specificity for malignancy was increased to 97 % ( p = 0.039) by also examining hepatic artery and portal vein blood supply coefficients, while maintaining a sensitivity of 76 %. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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