Influence of different drugs on HIV risk in people who inject: systematic review and meta-analysis.
Aims To assess systematically the risk of HIV acquisition by type of drug injected across different settings. Methods A systematic review and meta-analysis were conducted. Databases were searched for studies of HIV incidence in people who inject different drugs (PWID). Pooled HIV incidence rate rati...
| Publicado en: | Addiction Vol. 110; no. 4; pp. 572 - 585 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103776147&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103776147 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09652140 AIO jtl: Addiction issn: 09652140 maglogo: Y pubinfo: dt: Apr2015 vid: 110 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103776147 101555905 10.1111/add.12846 NLM25582153 103776147 ppf: 572 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Influence of different drugs on HIV risk in people who inject: systematic review and meta-analysis. aug: au: Tavitian-Exley, Isabel Vickerman, Peter Bastos, Francisco I. Boily, Marie-Claude affil: Department of Infectious Disease Epidemiology, Imperial College London sug: subj: HIV Infections Risk Factors Substance Abuse, Intravenous Street Drugs Classification Street Drugs Adverse Effects Human Systematic Review Meta Analysis Persons Who Use Intravenous Drugs Confidence Intervals Descriptive Statistics Embase Medline Odds Ratio Scales Female Male Female Male ab: Aims To assess systematically the risk of HIV acquisition by type of drug injected across different settings. Methods A systematic review and meta-analysis were conducted. Databases were searched for studies of HIV incidence in people who inject different drugs (PWID). Pooled HIV incidence rate ratio (IRR) was used to compare HIV risk between injecting and not-injecting a given drug, when possible, or otherwise with those reported not to have injected the substance. Pooled estimates of crude IRR were derived using random-effects models. Variations in IRR were assessed in subgroup analyses, by drug and geographical region. Results Of 5779 studies screened, 15 were included. HIV incidence was reported for people injecting cocaine (eight: North America, Europe), amphetamine-type stimulants (ATS) (four: Western and Eastern Europe, Asia), heroin (11: all settings), opiate-stimulants (four: North America, Western and Eastern Europe) and opiates-sedatives (five: Europe, Asia). HIV risk in cocaine injectors was 3.6 times 95% confidence interval (CI) = 2.8-4.7, I2 = 0%; n = 4) that of non-injectors and 3.0 for ATS injectors (95% CI = 2.2-4.1, I2 = 0%; n = 2). Higher sexual risk was reported in cohorts injecting stimulants. Compared to not-injecting, HIV IRR was 2.8 (95% CI = 1.7-4.7, I2 = 77%; n=6) for all heroin injectors and 3.5 (95% CI = 2.3-5.2, I2 = 40%; n=5) for heroin injectors in Asia and Europe. Conclusion The risk of HIV acquisition in people who inject drugs appears to vary by drug type but differences are not statistically significant, precluding conclusive grading of risk. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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