The Burden of Non-Adherence to Cardiovascular Medications Among the Aging Population in Australia: A Meta-Analysis.

Background: Non-adherence to cardiovascular medications is a problem worldwide, even in Australia, which has a socialized medical system, Medicare. Objective: The aim of this systematic review was to evaluate the burden of non-adherence to cardiovascular medications and factors thereof in Australia....

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Published in:Drugs & Aging Vol. 32; no. 3; pp. 217 - 226
Main Authors: McKenzie, Samantha, McLaughlin, Deirdre, Clark, Justin, Doi, Suhail
Format: meta analysis research tables/charts Journal Article
Published: Springer Nature Mar2015
Online Access:View this record in EBSCOhost
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      dt: Mar2015
      vid: 32
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      pub: Springer Nature
      place: New York, New York
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        atl: The Burden of Non-Adherence to Cardiovascular Medications Among the Aging Population in Australia: A Meta-Analysis.
      aug:
        au:
          McKenzie, Samantha
          McLaughlin, Deirdre
          Clark, Justin
          Doi, Suhail
        affil: The University of Queensland, School of Population Health, Herston Road, Herston Brisbane 4006 Australia
      sug:
        subj:
          Cardiovascular Diseases Drug Therapy
          Medication Compliance Evaluation
          Human
          Aging
          Meta Analysis
          Australia
          PubMed
          Embase
          CINAHL Database
          Psycinfo
          Cochrane Library
          Data Analysis, Statistical
          Economic Aspects of Illness
      ab: Background: Non-adherence to cardiovascular medications is a problem worldwide, even in Australia, which has a socialized medical system, Medicare. Objective: The aim of this systematic review was to evaluate the burden of non-adherence to cardiovascular medications and factors thereof in Australia. Data Sources: Pubmed, Embase, CINAHL, PsycInfo, Cochrane Library databases were searched. Eligibility Criteria: Articles were included if they were in English, peer-reviewed and provided empirical data on adherence to cardiovascular medication for an Australian cohort. Methods: A meta-analysis of prevalence of medication non-adherence using the double arcsine square root transformed proportion was undertaken. Studies were pooled in homogenous prevalence groups and factors that differed across groups were ascertained. Results: Five studies, including eight datasets and 76,867 subjects were analyzed. Three more or less homogenous prevalence categories were discernable: low [19 %, 95 % confidence interval (CI) 15-24], moderate (26 %, 95 % CI 23-29) and high (43 %, 95 % CI 43-44; this was a single study) prevalence of non-adherence. There were minimal clear patterns across groups in relation to typical factors of non-adherence (patient, condition, healthcare system or socioeconomic factors). Measurements used for non-adherence were similar for six of the eight included datasets, suggesting this did not affect prevalence of non-adherence or inclusion in a prevalence group. Conclusions: Non-adherence to cardiovascular medications is a serious problem in the aging Australian setting with an overall prevalence of between 14 and 43 %. The lack of patterns in the typical factors of non-adherence suggests that another factor, such as patients' beliefs about their conditions and medications, may be playing a stronger role in their non-adherence than clinical or sociodemographic factors. This is an area for further research.
      pubtype: Academic Journal
      doctype:
        meta analysis
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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