Short QTc Interval in Males with Klinefelter Syndrome-Influence of CAG Repeat Length, Body Composition, and Testosterone Replacement Therapy.
Background Klinefelter syndrome (KS) is a sex chromosomal aneuploidy (47,XXY) affecting 1/660 males. Based on findings in Turner syndrome, we hypothesized that electrocardiogram (ECG) abnormalities would be present in males with KS. Objective To investigate ECGs in males with KS and compare with con...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 38; no. 4; pp. 472 - 483 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103783840&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103783840 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Apr2015 vid: 38 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103783840 101830581 10.1111/pace.12580 NLM25615644 103783840 ppf: 472 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Short QTc Interval in Males with Klinefelter Syndrome-Influence of CAG Repeat Length, Body Composition, and Testosterone Replacement Therapy. aug: au: JØRgensen, Inger Norlyk SkakkebÆK, Anne Andersen, Niels Holmark Pedersen, Lisbeth NØRum Hougaard, David Michael Bojesen, Anders Trolle, Christian Gravholt, Claus HØJbjerg affil: Department of Endocrinology and Internal Medicine (MEA), Aarhus University Hospital sug: subj: Klinefelter's Syndrome Complications Heart Conduction System Abnormalities Testosterone Replacement Therapy Adverse Effects Electrocardiography Evaluation Mutation Human Male Descriptive Statistics Case Control Studies Intrarater Reliability Linear Regression Cross Sectional Studies Adolescence Young Adult Adult Middle Age Body Composition Karyotyping Blood Chemical Analysis Unpaired T-Tests Mann-Whitney U Test Chi Square Test Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Data Analysis Software Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Male ab: Background Klinefelter syndrome (KS) is a sex chromosomal aneuploidy (47,XXY) affecting 1/660 males. Based on findings in Turner syndrome, we hypothesized that electrocardiogram (ECG) abnormalities would be present in males with KS. Objective To investigate ECGs in males with KS and compare with controls. Methods Case control study of 62 males with KS and 62 healthy males matched on age. The primary outcome parameter was a difference in the ECG presentation between the two groups. The ECGs were analyzed by one blinded examiner (intraobserver variability 0.2-2.1%). The QT-interval was measured using 'teach-the-tangent' method excluding the U-wave. QTc was calculated using Bazett's equation, Hodges' equation, and a linear regression model. Body mass index, abdominal fat, and muscle mass as well as sex hormone levels were secondary parameters. The prevalence of mutations in genes related to short QT syndrome was determined in participants with a QTc < 330 ms. Results Compared to controls, the QTc-interval was shorter (P = 0.02-0.06) in males with KS depending on the applied correction method. QTc was shortest among testosterone (T)-treated males with KS, while untreated and thus hypogonadal KS had QTc interval comparable to controls. No mutations in genes related to short QT syndrome were found. Conclusion We found short QTc interval in males with KS, with further shortening of the QTc interval by T. These results suggest that genes on the X chromosome could be involved in regulation of the QTc interval and that T treatment may aggravate this mechanism. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|