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Selecting the Right Tool For the Job.

There are competing ethical concerns when it comes to designing any clinical research study. Clinical trials of possible treatments for Ebola virus are no exception. If anything, the competing ethical concerns are exacerbated in trying to find answers to a deadly, rapidly spreading, infectious disea...

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Published in:American Journal of Bioethics Vol. 15; no. 4; pp. 4 - 11
Main Authors: Caplan, Arthur L., Plunkett, Carolyn, Levin, Bruce
Format: Journal Article
Published: Taylor & Francis Ltd Apr2015
Online Access:View this record in EBSCOhost
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      dt: Apr2015
      vid: 15
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/15265161.2015.1010993
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        atl: Selecting the Right Tool For the Job.
      aug:
        au:
          Caplan, Arthur L.
          Plunkett, Carolyn
          Levin, Bruce
        affil: New York University Langone Medical Center
      sug:
        subj:
          Randomized Controlled Trials Ethical Issues
          Drugs, Investigational Ethical Issues
          Hemorrhagic Fever, Ebola Drug Therapy
          Clinical Research Ethical Issues
          Hemorrhagic Fever, Ebola Prevention and Control
          Research Ethics
          Placebo Effect Prevention and Control
          Africa, Western
          Therapeutic Trials
      ab: There are competing ethical concerns when it comes to designing any clinical research study. Clinical trials of possible treatments for Ebola virus are no exception. If anything, the competing ethical concerns are exacerbated in trying to find answers to a deadly, rapidly spreading, infectious disease. The primary goal of current research is to identify experimental therapies that can cure Ebola or cure it with reasonable probability in infected individuals. Pursuit of that goal must be methodologically sound, practical and consistent with prevailing norms governing human subjects research. Some maintain that only randomized controlled trials (RCTs) with a placebo or standard-of-care arm can meet these conditions. We maintain that there are alternative trial designs that can do so as well and that sometimes these are preferable to RCTs.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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