The Effect of ICD Programming on Inappropriate and Appropriate ICD Therapies in Ischemic and Nonischemic Cardiomyopathy: The MADIT-RIT Trial.
ICD Programming in Ischemic and Nonischemic Cardiomyopathy Introduction The MADIT-RIT trial demonstrated reduction of inappropriate and appropriate ICD therapies and mortality by high-rate cut-off and 60-second-delayed VT therapy ICD programming in patients with a primary prophylactic ICD indication...
| Published in: | Journal of Cardiovascular Electrophysiology Vol. 26; no. 4; pp. 424 - 434 |
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| Main Authors: | , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Apr2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103788167&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103788167 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Apr2015 vid: 26 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103788167 102043596 10.1111/jce.12605 NLM25546486 103788167 ppf: 424 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The Effect of ICD Programming on Inappropriate and Appropriate ICD Therapies in Ischemic and Nonischemic Cardiomyopathy: The MADIT-RIT Trial. aug: au: SedlÁČEk, Kamil Ruwald, Anne-Christine Kutyifa, Valentina Mcnitt, Scott Thomsen, Poul Erik Bloch Klein, Helmut Stockburger, Martin Wichterle, Dan Merkely, Bela Concha, Joaquin Fernandez Swissa, Moshe Zareba, Wojciech Moss, Arthur J. Kautzner, Josef Ruwald, Martin H. affil: Cardiology Department, Institute for Clinical and Experimental Medicine sug: subj: Myocardial Diseases Defibrillators, Implantable Utilization Human Funding Source Chi Square Test Wilcoxon Rank Sum Test Mortality Male Female Middle Age Aged Data Analysis Software Middle Aged: 45-64 years Aged: 65+ years Male Female ab: ICD Programming in Ischemic and Nonischemic Cardiomyopathy Introduction The MADIT-RIT trial demonstrated reduction of inappropriate and appropriate ICD therapies and mortality by high-rate cut-off and 60-second-delayed VT therapy ICD programming in patients with a primary prophylactic ICD indication. The aim of this analysis was to study effects of MADIT-RIT ICD programming in patients with ischemic and nonischemic cardiomyopathy. Methods and Results First and total occurrences of both inappropriate and appropriate ICD therapies were analyzed by multivariate Cox models in 791 (53%) patients with ischemic and 707 (47%) patients with nonischemic cardiomyopathy. Patients with ischemic and nonischemic cardiomyopathy had similar incidence of first inappropriate (9% and 11%, P = 0.21) and first appropriate ICD therapy (11.6% and 14.1%, P = 0.15). Patients with ischemic cardiomyopathy had higher mortality rate (6.1% vs. 3.3%, P = 0.01). MADIT-RIT high-rate cut-off (arm B) and delayed VT therapy ICD programming (arm C) compared with conventional (arm A) ICD programming were associated with a significant risk reduction of first inappropriate and appropriate ICD therapy in patients with ischemic and nonischemic cardiomyopathy (HR range 0.11-0.34, P < 0.001 for all comparisons). Occurrence of total inappropriate and appropriate ICD therapies was significantly reduced by high-rate cut-off ICD programming and delayed VT therapy ICD programming in both ischemic and nonischemic cardiomyopathy patients. Conclusion High-rate cut-off and delayed VT therapy ICD programming are associated with significant reduction in first and total inappropriate and appropriate ICD therapy in patients with ischemic and nonischemic cardiomyopathy. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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