Pulmonary Function Testing and Outcomes in Subjects With Heart Failure Listed for Heart Transplantation.
BACKGROUND: Impaired spirometric parameters have been reported in patients with stage C heart failure and portend worse outcomes in these patients. The impact of spirometric parameters on outcomes in patients with stage D heart failure listed for heart transplantation is unknown. METHODS: We collect...
| Publicado en: | Respiratory Care Vol. 60; no. 5; pp. 731 - 740 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
May2015
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103800848&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103800848 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: May2015 vid: 60 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 103800848 102727853 10.4187/respcare.03709 NLM25737570 103800848 ppf: 731 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Pulmonary Function Testing and Outcomes in Subjects With Heart Failure Listed for Heart Transplantation. aug: au: Georgiopoulou, Vasiliki V Deka, Anjan Song Li Niazi, Anum A Farooq, Kanwal Kalogeropoulos, Andreas P Butler, Javed Alexopoulos, Dimitrios affil: Emory Clinical Cardiovascular Research Institute, Emory University, Atlanta, Georgia; Department of Cardiology, University of Patras, Patras, Greece sug: subj: Spirometry Heart Failure Physiopathology Treatment Outcomes Heart Transplantation Vital Capacity Human Male Female Descriptive Statistics Data Analysis Software Confidence Intervals Odds Ratio Cox Proportional Hazards Model Adult Middle Age Aged Forced Expiratory Volume Hemodynamics Respiratory Function Tests Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: BACKGROUND: Impaired spirometric parameters have been reported in patients with stage C heart failure and portend worse outcomes in these patients. The impact of spirometric parameters on outcomes in patients with stage D heart failure listed for heart transplantation is unknown. METHODS: We collected data on consecutive subjects listed for heart transplantation and examined the association of FEV1, FVC, and FEV1/FVC with (1) death or left ventricular assist device implantation (primary end point) and (2) death, left ventricular assist device implantation, or urgent transplantation (secondary end point). In a secondary analysis, we examined the association of baseline spirometry with post-transplant outcomes. RESULTS: Among 187 subjects (53 ± 10 y old, 17.1% women, 69.5% white subjects, 28.9% black subjects), there were 19 deaths, 28 left ventricular assist device implantations, and 74 urgent transplantations (primary end point of 25.1%, secondary end point of 64.7%) after a median of 5.5 months (interquartile range of 2.3-15.2). For FEV1, the hazard ratios for the primary and secondary end points were 0.93 (95% CI 0.61-1.41, P = .72) and 0.94 (95% CI 0.72-1.21, P = .62) per L, respectively. The hazard ratios of FVC were 0.90 (95% CI 0.65-1.25, P = .52) and 0.92 (95% CI 0.76-1.13, P = .43) per L, respectively. Impairment patterns (obstructive, restrictive, mixed) were not associated with risk for events. There was no interaction of spirometric parameters with smoking or lung disease for outcomes. Baseline spirometry was not associated with perioperative 30-d mortality (1.4%) and 1-y post-transplant survival (97.1%). CONCLUSIONS: In contrast to stage C subjects with heart failure, spirometric parameters were not associated with outcomes in this homogeneous stage D heart failure population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|