PCL/PHBV microparticles as innovative carriers for oral controlled release of manidipine dihydrochloride.
Microparticles of poly(ε-caprolactone) (PCL) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) containing manidipine dihydrochloride (MAN) were successfully prepared by the simple emulsion/solvent evaporation method. All formulations showed loading efficiency rates greater than 80% and average...
| Publicado en: | Scientific World Journal pp. 268107 - 268108 |
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| Autores principales: | , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103811297&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103811297 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1537744X 1BX5 jtl: Scientific World Journal issn: 1537744X maglogo: N pubinfo: dt: 2014 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103811297 103811297 NLM24550699 2012482038 10.1155/2014/268107 NLM24550699 PMC3914481 103811297 ppf: 268107 ppct: 1 formats: tig: atl: PCL/PHBV microparticles as innovative carriers for oral controlled release of manidipine dihydrochloride. aug: au: Barboza, Fernanda Malaquias Machado, Willian Moreira Olchanheski Junior, Luiz Renato Padilha de Paula, Josiane Zawadzki, Sônia Faria Fernandes, Daniel Farago, Paulo Vitor affil: Laboratory of Pharmaceutical Products, Postgraduate Program in Pharmaceutical Science, Department of Pharmaceutical Sciences, State University of Ponta Grossa, 4748 Carlos Cavalcanti Avenue, 84030-900 Ponta Grossa, PR, Brazil. sug: subj: Delayed-Action Preparations Pyridines Administration and Dosage Pyridines Pharmacokinetics Drug Delivery Systems Polyesters Antihypertensive Agents Administration and Dosage Antihypertensive Agents Pharmacokinetics Female Particle Size Rats Spectrophotometry, Infrared Surface Properties Physics X-Rays Animal Studies Female ab: Microparticles of poly(ε-caprolactone) (PCL) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) containing manidipine dihydrochloride (MAN) were successfully prepared by the simple emulsion/solvent evaporation method. All formulations showed loading efficiency rates greater than 80% and average particle size less than 8 μm. Formulations had spherical shape with smooth and porous surface for PCL and PHBV, respectively. According to Fourier-transform infrared spectroscopy, initial components were not chemically modified during microencapsulation. X-ray diffraction patterns and differential scanning calorimetry demonstrated that this process led to drug amorphization. In vitro dissolution studies showed that all microparticles prolonged MAN release, mainly which one obtained using PCL that contained 5% of drug loaded (PCL-M5). Animal studies demonstrated that formulation PCL-M5 was able to keep the variation of mean arterial pressure after phenylephrine administration up to 24 hours. These data confirmed the sustained antihypertensive effect of the investigated microparticles. Results provided an experimental basis for using formulation PCL-M5 as a feasible carrier for oral controlled release of MAN intended for treating high blood pressure. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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