Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.
Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide implicated in addiction to drugs of abuse. Several studies have characterized the role of CART in addiction to psychostimulants, but few have examined the role of CART in alcohol use disorders including alcoholism. The current st...
| Publicado en: | Addiction Biology Vol. 19; no. 2; pp. 175 - 185 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Mar2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103812224&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103812224 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13556215 ADB jtl: Addiction Biology issn: 13556215 maglogo: Y pubinfo: dt: Mar2014 vid: 19 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103812224 103812224 NLM22823101 2012495036 10.1111/j.1369-1600.2012.00475.x NLM22823101 PMC4148419 103812224 ppf: 175 ppct: 10 formats: tig: atl: Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice. aug: au: Salinas, Armando G Nguyen, Chinh T Q Ahmadi-Tehrani, Dara Morrisett, Richard A affil: Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA. sug: subj: Alcohol Drinking Behavior Ethanol Administration and Dosage Food Preferences Nerve Tissue Proteins Physiology Reproduction Analgesics, Nonnarcotic Administration and Dosage Animal Studies Brain Metabolism Decision Making Dose-Response Relationship, Drug Ethanol Metabolism Ethanol Pharmacodynamics Female Genetic Techniques Genotype Immunohistochemistry Male Mice Models, Biological Nerve Tissue Proteins Nerve Tissue Proteins Metabolism Quinine Administration and Dosage Reflex Drug Effects Saccharin Administration and Dosage Sweetening Agents Administration and Dosage Water Supply Female Male ab: Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide implicated in addiction to drugs of abuse. Several studies have characterized the role of CART in addiction to psychostimulants, but few have examined the role of CART in alcohol use disorders including alcoholism. The current study utilized a CART knockout (KO) mouse model to investigate the role of CART in ethanol appetitive behaviors. A two-bottle choice, unlimited-access paradigm was used to compare ethanol appetitive behaviors between CART wild type (WT) and KO mice. The mice were presented with an ethanol solution (3%-21%) and water, each concentration for 4 days, and their consumption was measured daily. Consumption of quinine (bitter) and saccharin (sweet) solutions was measured following the ethanol preference tests. In addition, ethanol metabolism rates and ethanol sensitivity were compared between genotypes. CART KO mice consumed and preferred ethanol less than their WT counterparts in both sexes. This genotype effect could not be attributed to differences in bitter or sweet taste perception or ethanol metabolism rates. There was also no difference in ethanol sensitivity in male mice; however, CART KO female mice showed a greater ethanol sensitivity than the WT females. Taken together, these data demonstrate a role for CART in ethanol appetitive behaviors and as a possible therapeutic drug target for alcoholism and abstinence enhancement. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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