A synthetic tryptophan metabolite reduces hemorrhagic area and inflammation after pulmonary radiofrequency ablation in rabbit nonneoplastic lungs.
Purpose: The purpose of this study was to determine the effect of a synthetic tryptophan metabolite, tranilast [N-(3,4-dimethoxycinnamoyl)-anthranilic acid], on inflammatory and hemorrhagic areas after pulmonary radiofrequency ablation (RFA) in rabbits.Materials and Methods: Percutaneous RFA using a...
| Publicado en: | Japanese Journal of Radiology Vol. 32; no. 3; pp. 145 - 155 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103813811&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103813811 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: Mar2014 vid: 32 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103813811 NLM24448965 2012516359 10.1007/s11604-014-0282-4 NLM24448965 103813811 ppf: 145 ppct: 10 formats: fmt: @attributes: type: P tig: atl: A synthetic tryptophan metabolite reduces hemorrhagic area and inflammation after pulmonary radiofrequency ablation in rabbit nonneoplastic lungs. aug: au: Nakada, Hiroshi Yamashita, Atsushi Kuroki, Masaomi Furukoji, Eiji Uchino, Noriko Asanuma, Taketoshi Asada, Yujiro Tamura, Shozo affil: Department of Radiology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan, nkdhrs@med.miyazaki-u.ac.jp. sug: subj: Antiinflammatory Agents, Non-Steroidal Therapeutic Use Catheter Ablation Adverse Effects Hemorrhage Drug Therapy Inflammation Drug Therapy Surgery, Lung Acids, Carbocyclic Therapeutic Use Animals Models, Biological Prospective Studies Hemorrhage Etiology Inflammation Etiology Rabbits Treatment Outcomes ab: Purpose: The purpose of this study was to determine the effect of a synthetic tryptophan metabolite, tranilast [N-(3,4-dimethoxycinnamoyl)-anthranilic acid], on inflammatory and hemorrhagic areas after pulmonary radiofrequency ablation (RFA) in rabbits.Materials and Methods: Percutaneous RFA using a 17-gauge LeVeen electrode was performed in normal rabbit lungs. The rabbits were divided into tranilast-treated (300 mg/kg/day, orally) and control groups (n = 24/group). The effects of tranilast were evaluated using multidetector-row computed tomography (CT), histology, and immunohistochemistry immediately after RFA on days 1, 7, 14, and 28.Results: Oral administration of tranilast significantly reduced the size of ablated lesions assessed using CT and histology on days 7 and 14. Furthermore, it reduced the hemorrhagic areas on day 7 and inflammatory areas on day 14, but did not affect the areas of coagulation necrosis on days 1, 7, 14, and 28. Immunohistochemical analysis showed an increase in the ratio of CD163-positive macrophage areas to rabbit macrophage (RAM11)-positive pan-macrophage areas and a decrease in the number of nuclear factor-κB-positive nuclei and CD31-positive microvessels in the tranilast group on days 7 and/or 14.Conclusions: The results suggest that tranilast modulates the repair process after pulmonary RFA through macrophage accumulation, suppression of inflammation, and angiogenesis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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