Heritable changes in regional cortical thickness with age.
It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expre...
| Publicado en: | Brain Imaging & Behavior Vol. 8; no. 2; pp. 208 - 217 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103821364&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103821364 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Jun2014 vid: 8 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103821364 NLM24752552 2012571242 10.1007/s11682-014-9296-x NLM24752552 PMC4205107 103821364 ppf: 208 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Heritable changes in regional cortical thickness with age. aug: au: Chouinard-Decorte, Francois McKay, D Reese Reid, Andrew Khundrakpam, Budhachandra Zhao, Lu Karama, Sherif Rioux, Pierre Sprooten, Emma Knowles, Emma Kent Jr, Jack W Curran, Joanne E Göring, Harald H H Dyer, Thomas D Olvera, Rene L Kochunov, Peter Duggirala, Ravi Fox, Peter T Almasy, Laura Blangero, John Bellec, Pierre sug: subj: Aging Cerebral Cortex Pathology Adolescence Adult Aged Family Female Hispanic Americans Image Processing, Computer Assisted Methods Magnetic Resonance Imaging Methods Male Middle Age Body Weights and Measures Phenotype Young Adult Adolescent: 13-18 years Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: It is now well established that regional indices of brain structure such as cortical thickness, surface area or grey matter volume exhibit spatially variable patterns of heritability. However, a recent study found these patterns to change with age during development, a result supported by gene expression studies. Changes in heritability have not been investigated in adulthood so far and could have important implications in the study of heritability and genetic correlations in the brain as well as in the discovery of specific genes explaining them. Herein, we tested for genotype by age (G ×A) interactions, an extension of genotype by environment interactions, through adulthood and healthy aging in 902 subjects from the Genetics of Brain Structure (GOBS) study. A "jackknife" based method for the analysis of stable cortical thickness clusters (JASC) and scale selection is also introduced. Although additive genetic variance remained constant throughout adulthood, we found evidence for incomplete pleiotropy across age in the cortical thickness of paralimbic and parieto-temporal areas. This suggests that different genetic factors account for cortical thickness heritability at different ages in these regions. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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