Performance evaluation of stationary and semi-stationary acquisition with a non-stationary small animal multi-pinhole SPECT system.
Purpose: Step-and-shoot mode with many angular steps results in long frame duration limiting the capability of single-photon emission computed tomography (SPECT) for fast dynamic scans. The present study evaluates acquisition with reduced angular sampling for fast imaging in preclinical research wit...
| Publicado en: | Molecular Imaging & Biology Vol. 16; no. 3; pp. 311 - 317 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103822206&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103822206 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Jun2014 vid: 16 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103822206 NLM24214814 2012574940 10.1007/s11307-013-0702-3 NLM24214814 103822206 ppf: 311 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Performance evaluation of stationary and semi-stationary acquisition with a non-stationary small animal multi-pinhole SPECT system. aug: au: Lange, Catharina Apostolova, Ivayla Lukas, Mathias Huang, Kai P Hofheinz, Frank Gregor-Mamoudou, Betina Brenner, Winfried Buchert, Ralph affil: Department of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany. sug: subj: Tomography, Emission-Computed, Single-Photon Equipment and Supplies Animal Studies Iodine Radioisotopes Mice Organic Chemicals ab: Purpose: Step-and-shoot mode with many angular steps results in long frame duration limiting the capability of single-photon emission computed tomography (SPECT) for fast dynamic scans. The present study evaluates acquisition with reduced angular sampling for fast imaging in preclinical research with the nanoSPECT/CTplus four-head multi-pinhole system.Procedures: Measurements with line sources, homogeneity phantoms and a Jaszczak phantom filled with (99m)Tc or (123)I were performed to evaluate the 'stationary' and 'semi-stationary' acquisition mode (one or two detector positions, respectively) with respect to spatial resolution, quantification, noise properties and image artefacts. An in vivo mouse study was performed with (99m)Tc-MAG3.Results: The fast acquisition modes resulted in only minor degradation of spatial resolution and quantification accuracy. Statistical noise in reconstructed images was significantly reduced compared to conventional SPECT, particularly at low count statistics. Stationary acquisition resulted in streak artefacts and spatial distortion.Conclusions: The semi-stationary acquisition mode of the nanoSPECT/CTplus allows fast dynamic SPECT with tolerable loss of image quality. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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