Parametric response mapping of dynamic CT as an imaging biomarker to distinguish viability of hepatocellular carcinoma treated with transcatheter arterial chemoembolization.
Purpose: Accurate assessment of viability of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) is important for therapy planning. The purpose of this study is to determine the diagnostic value of a novel image analysis method called parametric response mapping (PRM...
| Publicado en: | Abdominal Imaging Vol. 39; no. 3; pp. 518 - 526 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jun2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103825783&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103825783 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09428925 O52 jtl: Abdominal Imaging issn: 09428925 maglogo: N pubinfo: dt: Jun2014 vid: 39 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103825783 NLM24519566 2012600979 10.1007/s00261-014-0087-z NLM24519566 103825783 ppf: 518 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Parametric response mapping of dynamic CT as an imaging biomarker to distinguish viability of hepatocellular carcinoma treated with transcatheter arterial chemoembolization. aug: au: Choi, Seung Joon Kim, Jonghoon Seo, Jongbum Kim, Hyung Sik Lee, Jong-Min Park, Hyunjin affil: Department of Radiology, Gachon University Gil Hospital, Incheon, Korea. sug: subj: Carcinoma, Hepatocellular Radiography Carcinoma, Hepatocellular Therapy Liver Neoplasms Radiography Liver Neoplasms Therapy Radiographic Image Interpretation, Computer-Assisted Methods Tumor Markers, Biological Aged Pharmacokinetics Chemoembolization, Therapeutic Methods Contrast Media Diagnostic Use Female Human Contrast Media Male Middle Age Observer Bias ROC Curve Radiographic Image Enhancement Methods Reproducibility of Results Retrospective Design Sensitivity and Specificity Tomography, X-Ray Computed Methods Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Purpose: Accurate assessment of viability of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) is important for therapy planning. The purpose of this study is to determine the diagnostic value of a novel image analysis method called parametric response mapping (PRM) in predicting viability of tumor in HCC treated with TACE for dynamic CT images. Methods: 35 patients who had 35 iodized-oil defect areas (IODAs) in HCCs treated with TACE were included in our study. These patients were divided into two groups, one group with viable tumors (n = 22) and the other group with non-viable tumors (n = 13) in the IODA. All patients were followed up using triple-phase dynamic CT after the treatment. We compared (a) manual analysis, (b) using PRM results, and (c) using PRM results with automatic classifier to distinguish between two tumor groups based on dynamic CT images from two longitudinal exams. Two radiologists performed the manual analysis. The PRM approach was implemented using prototype software. We adopted an off-the-shelf k nearest neighbor (kNN) classifier and leave-one-out cross-validation for the third approach. The area under the curve (AUC) values were compared for three approaches. Results: Manual analysis yielded AUC of 0.74, using PRM results yielded AUC of 0.84, and using PRM results with an automatic classifier yielded AUC of 0.87. Conclusions: We improved upon the standard manual analysis approach by adopting a novel image analysis method of PRM combined with an automatic classifier. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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