Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty acid homeostasis and insulin resistance.
Objective: Fatty acid (FA) metabolism is tightly regulated across several tissues and impacts insulin sensitivity. CD36 facilitates cellular FA uptake, and CD36 genetic variants associate with lipid abnormalities and susceptibility to metabolic syndrome. The objective of this study was to gain insig...
| Publicado en: | Diabetes Care Vol. 37; no. 7; pp. 1990 - 1998 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
American Diabetes Association
Jul2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103830779&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103830779 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01495992 1G7 jtl: Diabetes Care issn: 01495992 maglogo: N pubinfo: dt: Jul2014 vid: 37 iid: 7 pid: 1367 pub: American Diabetes Association place: Arlington, Virginia artinfo: ui: 103830779 NLM24784828 2012629211 10.2337/dc13-2835 NLM24784828 PMC4067395 103830779 ppf: 1990 ppct: 8 formats: tig: atl: Adipose and muscle tissue profile of CD36 transcripts in obese subjects highlights the role of CD36 in fatty acid homeostasis and insulin resistance. aug: au: Pietka, Terri A Schappe, Timothy Conte, Caterina Fabbrini, Elisa Patterson, Bruce W Klein, Samuel Abumrad, Nada A Love-Gregory, Latisha affil: Department of Medicine, Center for Human Nutrition, Washington University, St Louis, MO. sug: subj: Adipose Tissue Metabolism Antigens, Surface Metabolism Insulin Resistance Obesity Metabolism Adipocytes Metabolism Adult Fatty Acids Metabolism Female Glucose Metabolism Glucose Clamp Technique Homeostasis Human Liver Metabolism Male Muscle, Skeletal Metabolism Triglycerides Metabolism Adult: 19-44 years Female Male ab: Objective: Fatty acid (FA) metabolism is tightly regulated across several tissues and impacts insulin sensitivity. CD36 facilitates cellular FA uptake, and CD36 genetic variants associate with lipid abnormalities and susceptibility to metabolic syndrome. The objective of this study was to gain insight regarding the in vivo metabolic influence of muscle and adipose tissue CD36. For this, we determined the relationships between CD36 alternative transcripts, which can reflect tissue-specific CD36 regulation, and measures of FA metabolism and insulin resistance.Research Design and Methods: The relative abundance of alternative CD36 transcripts in adipose tissue and skeletal muscle from 53 nondiabetic obese subjects was measured and related to insulin sensitivity and FA metabolism assessed by hyperinsulinemic-euglycemic clamps and isotopic tracers for glucose and FA.Results: Transcript 1C, one of two major transcripts in adipose tissue, that is restricted to adipocytes predicted systemic and tissue (adipose, liver, and muscle) insulin sensitivity, suggesting adipocyte CD36 protects against insulin resistance. Transcripts 1B and 1A, the major transcripts in skeletal muscle, correlated with FA disposal rate and triglyceride clearance, supporting importance of muscle CD36 in clearance of circulating FA. Additionally, the common CD36 single nucleotide polymorphism rs1761667 selectively influenced CD36 transcripts and exacerbated insulin resistance of glucose disposal by muscle.Conclusions: Alternative CD36 transcripts differentially influence tissue CD36 and consequently FA homeostasis and insulin sensitivity. Adipocyte CD36 appears to be metabolically protective, and its selective upregulation might have therapeutic potential in insulin resistance. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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