Long range frontal/posterior phase synchronization during remembered pursuit task is impaired in schizophrenia.
Although smooth pursuit eye movement (SPEM) is a reliable endophenotype of schizophrenia, exact underlying cognitive and neural substrates remain unknown. A simple mechanistic model of SPEM assumes an efficient interaction in integrating sensory input from the medial temporal (MT)/medial superior te...
| Publicado en: | Schizophrenia Research Vol. 157; no. 1-3; pp. 198 - 204 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Aug2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103833725&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103833725 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: Aug2014 vid: 157 iid: 1-3 pid: 1004 pub: Elsevier B.V. artinfo: ui: 103833725 NLM24951402 2012647295 10.1016/j.schres.2014.05.035 NLM24951402 PMC4127487 103833725 ppf: 198 ppct: 6 formats: tig: atl: Long range frontal/posterior phase synchronization during remembered pursuit task is impaired in schizophrenia. aug: au: Krishna, Nithin O'Neill, Hugh Sánchez-Morla, Eva María Thaker, Gunvant K affil: Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, United States. Electronic address: nkrishna@psych.umaryland.edu. sug: subj: Brain Physiopathology Memory Eye Movements Physiology Schizophrenia Physiopathology Adult Electroencephalography Cues Phenotype Female Human Male Models, Biological Neuropsychological Tests Physical Stimulation Adult: 19-44 years Female Male ab: Although smooth pursuit eye movement (SPEM) is a reliable endophenotype of schizophrenia, exact underlying cognitive and neural substrates remain unknown. A simple mechanistic model of SPEM assumes an efficient interaction in integrating sensory input from the medial temporal (MT)/medial superior temporal (MST) brain regions and subsequent motor response through the frontal eye field (FEF). Poor functional connectivity between these two regions could explain impaired motion perception and SPEM maintenance in schizophrenia. In the present study, we combined an eye tracking paradigm with electroencephalography (EEG) recordings to investigate the putative functional connectivity among frontal/posterior brain regions in mediating the modulation of SPEM. Twenty four schizophrenic (SZ) and 22 healthy control (HC) participants performed remembered pursuit tasks with EEG recordings. Behaviorally, HC subjects showed significant improvement in SPEM response on repeated presentations of target compared to SZ subjects. Neurophysiologically HC subjects showed higher frontal/posterior phase synchronization in the beta to low gamma range frequency bands during all target presentations. In addition there was a significant increase in phase synchronization in the beta-2 frequency band in HC subjects during late compared to early target presentation. In contrast, higher frontal/posterior phase synchronization in the beta-2 frequency predicted better performance during late target presentation and lower enduring psychosis in SZ subjects. These data suggest a pathologically perturbed connectivity between frontal and posterior cortical regions during SPEM in SZ. The integrative eye tracking-EEG approach used in this study to dissect the endophenotype may reveal novel targets for studying schizophrenia psychopathology. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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