Incidence for progression of hypervascular HCC in hypovascular hepatic nodules showing hyperintensity on gadoxetic acid-enhanced hepatobiliary phase in patients with chronic liver diseases.
Purpose: The purpose of this study was to elucidate the incidence and risk factors for the progression of hyperintense nodules, observed in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI), to hyperv...
| Publicado en: | Japanese Journal of Radiology Vol. 32; no. 7; pp. 405 - 414 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jul2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103835611&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103835611 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: Jul2014 vid: 32 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103835611 NLM24854900 2012656842 10.1007/s11604-014-0323-z NLM24854900 103835611 ppf: 405 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Incidence for progression of hypervascular HCC in hypovascular hepatic nodules showing hyperintensity on gadoxetic acid-enhanced hepatobiliary phase in patients with chronic liver diseases. aug: au: Matsuda, Megumi Tsuda, Takaharu Yoshioka, Shinji Murata, Shigetoshi Tanaka, Hiroaki Hirooka, Masashi Hiasa, Yoichi Mochizuki, Teruhito affil: Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan, megumi@m.ehime-u.ac.jp. sug: subj: Carcinoma, Hepatocellular Blood Supply Carcinoma, Hepatocellular Epidemiology Disease Progression Contrast Media Diagnostic Use Liver Neoplasms Blood Supply Liver Neoplasms Epidemiology Magnetic Resonance Imaging Methods Aged Aged, 80 and Over Carcinoma, Hepatocellular Diagnosis Chronic Disease Comorbidity Female Human Image Enhancement Methods Incidence Kaplan-Meier Estimator Liver Blood Supply Liver Pathology Liver Radiography Liver Diseases Epidemiology Liver Diseases Pathology Liver Diseases Radiography Liver Neoplasms Diagnosis Male Middle Age Retrospective Design Risk Factors Tomography, X-Ray Computed Methods Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: The purpose of this study was to elucidate the incidence and risk factors for the progression of hyperintense nodules, observed in the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI), to hypervascular hepatocellular carcinoma (HCC).Materials and Methods: Hypovascular nodules (n = 157) showing hyperintensity in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI were examined in 41 patients. All patients underwent computed tomography (CT) during hepatic arteriography and CT during arterial portography within one month of Gd-EOB-DTPA-enhanced MRI. The incidence of progression to hypervascular or classical HCC was calculated using the Kaplan-Meier method.Results: Tumor size was determined by univariate and multivariate analysis to be an important risk factor of hypervascularization (p = 0.041, odds ratio 1.135). The cumulative incidences of hypervascularization in hypovascular nodules showing hyperintensity on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI were 2.4, 4.5, and 6.2 % at 12, 24, and 36 months, respectively. The incidence of hypervascularization was significantly increased in nodules >10 mm in diameter (p = 0.00035).Conclusion: In patients with chronic liver disease, hypovascular nodules presenting as hyperintense in the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI and >10 mm in diameter have malignant potential for progression to hypervascular HCC and require careful management. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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