A national drug related problems database: evaluation of use in practice, reliability and reproducibility.
Background: A drug related problems database (DRP-database) was developed on request by clinical pharmacists. The information from the DRP-database has only been used locally e.g. to identify focus areas and to communicate identified DRPs to the hospital wards. Hence the quality of the data at the n...
| Published in: | International Journal of Clinical Pharmacy Vol. 36; no. 4; pp. 742 - 750 |
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| Main Authors: | , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Aug2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103838078&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103838078 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 22107703 BGX3 jtl: International Journal of Clinical Pharmacy issn: 22107703 maglogo: N pubinfo: dt: Aug2014 vid: 36 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103838078 NLM24899212 2012670567 10.1007/s11096-014-9957-2 NLM24899212 103838078 ppf: 742 ppct: 8 formats: tig: atl: A national drug related problems database: evaluation of use in practice, reliability and reproducibility. aug: au: Kjeldsen, Lene Juel Birkholm, Trine Fischer, Hanne Graabæk, Trine Hansen, Merete Kjær Kibsdal, Karina Porsborg Ravn-Nielsen, Lene Vestergaard Truelshøj, Tania Holtum affil: The Danish Research Unit for Hospital Pharmacy, Amgros I/S, Dampfærgevej 22, 2100, Copenhagen, Denmark, ljk@amgros.dk. sug: subj: Adverse Drug Event Medication Reconciliation National Health Programs Pharmacy and Pharmacology Labor Supply Pharmacy Service Labor Supply Drugs, Prescription Adverse Effects Quality of Health Care Denmark Drug Monitoring Drug Therapy, Combination Adverse Effects Electronic Health Records Prospective Studies Guideline Adherence Human Practice Patterns Practice Guidelines Drugs, Prescription Administration and Dosage Drugs, Prescription Therapeutic Use Reproducibility of Results ab: Background: A drug related problems database (DRP-database) was developed on request by clinical pharmacists. The information from the DRP-database has only been used locally e.g. to identify focus areas and to communicate identified DRPs to the hospital wards. Hence the quality of the data at the national level is unknown, which may compromise national analyses for benchmarking and identification of national focus areas.Objective: The aim of the study was to evaluate the use in practice, reliability and reproducibility of the DRPs documented in the Danish drug related problems database.Setting: Danish hospital pharmacies.Methods: Practice use of the DRP-database was explored by an electronic questionnaire distributed to hospital pharmacies, and consisted of questions regarding current and previous use of the DRP-database. The reliability was evaluated by comparing the categorization of 24 cases by clinical pharmacists with categorization performed by the project group. Reproducibility was explored by re-categorization of a sample of existing records in the DRP-database by two project group members individually.Main Outcome Measures: Observed proportion of agreement and Fleiss' kappa as measures of inter-rater reliability and reproducibility.Results: The practice use study of 12 hospital pharmacy locations revealed that when implementing the DRP-database, the majority of identified DRPs are documented in the DRP-database, however, some variations throughout the country exist. The interrater reliability study of 34 clinical pharmacists showed high inter-rater reliability with the project group (Fleiss' kappa = 0.79 with 95 % CI (0.70; 0.88)), and the reproducibility study also documented high inter-rater reliability of a sample of 379 records from the DRP-database re-categorized by two project group members (Fleiss' kappa = 0.81 with 95 % CI (0.78; 0.85)).Conclusion: The study showed high reliability and reproducibility of the DRP-database, however, some local variation in the use of the DRP-database throughout the country existed affecting the overall quality. These findings indicate that data in the DRP-database may be pooled, and national analyses may be conducted to explore development areas for common interest. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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