Effect of inspiration on airway dimensions measured in maximal inspiration CT images of subjects without airflow limitation.
Objectives: To study the effect of inspiration on airway dimensions measured in voluntary inspiration breath-hold examinations.Methods: 961 subjects with normal spirometry were selected from the Danish Lung Cancer Screening Trial. Subjects were examined annually for five years with low-dose CT. Auto...
| Published in: | European Radiology Vol. 24; no. 9; pp. 2319 - 2326 |
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| Main Authors: | , , , , , , , |
| Format: | research randomized controlled trial Journal Article |
| Published: |
Springer Nature
Sep2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103839205&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103839205 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2014 vid: 24 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103839205 NLM24903230 2012677135 10.1007/s00330-014-3261-3 NLM24903230 103839205 ppf: 2319 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effect of inspiration on airway dimensions measured in maximal inspiration CT images of subjects without airflow limitation. aug: au: Petersen, Jens Wille, Mathilde M W Rakêt, Lars Lau Feragen, Aasa Pedersen, Jesper H Nielsen, Mads Dirksen, Asger de Bruijne, Marleen affil: Department of Computer Science, University of Copenhagen, Nørre Campus, Universitetsparken 5, 2100, Copenhagen ø, Denmark, phup@diku.dk. sug: subj: Early Detection of Cancer Methods Inspiration, Respiratory Physiology Lung Neoplasms Radiography Multidetector Computed Tomography Methods Respiratory System Radiography Aged Female Prospective Studies Human Lung Neoplasms Physiopathology Male Middle Age Reproducibility of Results Respiratory System Physiopathology Time Factors Total Lung Capacity Aged: 65+ years Middle Aged: 45-64 years Female Male ab: Objectives: To study the effect of inspiration on airway dimensions measured in voluntary inspiration breath-hold examinations.Methods: 961 subjects with normal spirometry were selected from the Danish Lung Cancer Screening Trial. Subjects were examined annually for five years with low-dose CT. Automated software was utilized to segment lungs and airways, identify segmental bronchi, and match airway branches in all images of the same subject. Inspiration level was defined as segmented total lung volume (TLV) divided by predicted total lung capacity (pTLC). Mixed-effects models were used to predict relative change in lumen diameter (ALD) and wall thickness (AWT) in airways of generation 0 (trachea) to 7 and segmental bronchi (R1-R10 and L1-L10) from relative changes in inspiration level.Results: Relative changes in ALD were related to relative changes in TLV/pTLC, and this distensibility increased with generation (p < 0.001). Relative changes in AWT were inversely related to relative changes in TLV/pTLC in generation 3--7 (p < 0.001). Segmental bronchi were widely dispersed in terms of ALD (5.7 ± 0.7 mm), AWT (0.86 ± 0.07 mm), and distensibility (23.5 ± 7.7%).Conclusions: Subjects who inspire more deeply prior to imaging have larger ALD and smaller AWT. This effect is more pronounced in higher-generation airways. Therefore, adjustment of inspiration level is necessary to accurately assess airway dimensions.Key Points: Airway lumen diameter increases and wall thickness decreases with inspiration. The effect of inspiration is greater in higher-generation (more peripheral) airways. Airways of generation 5 and beyond are as distensible as lung parenchyma. Airway dimensions measured from CT should be adjusted for inspiration level. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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