Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: an MRI evaluation.
Objectives: To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements.Methods: A total of 100 healthy adults (gender and age eve...
| Published in: | European Radiology Vol. 24; no. 9; pp. 2069 - 2077 |
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| Main Authors: | , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Sep2014
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103839215&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103839215 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2014 vid: 24 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103839215 NLM24972952 2012677144 10.1007/s00330-014-3265-z NLM24972952 103839215 ppf: 2069 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Effects of gender, age, and body mass index on fat contents and apparent diffusion coefficients in healthy parotid glands: an MRI evaluation. aug: au: Chang, Hing-Chiu Juan, Chun-Jung Chiu, Hui-Chu Cheng, Cheng-Chieh Chiu, Su-Chin Liu, Yi-Jui Chung, Hsiao-Wen Hsu, Hsian-He affil: Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan. sug: subj: Adipose Tissue Anatomy and Histology Body Mass Index Magnetic Resonance Imaging Methods Imaging, Three-Dimensional Methods Parotid Gland Anatomy and Histology Adult Age Factors Aged, 80 and Over Female Human Male Middle Age Prospective Studies Reference Values Sex Factors Adult: 19-44 years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Objectives: To establish standard apparent diffusion coefficient (ADC) and the fat content as a function of age, gender and body mass index (BMI) in healthy parotid glands, and to address the influences of fat suppression on ADC measurements.Methods: A total of 100 healthy adults (gender and age evenly distributed) were prospectively recruited, with parotid fat content measured from gradient-echo images with fat-water separated using iterative decomposition with echo asymmetry and least squares (IDEAL). The ADCs were estimated using both fat-saturated and non-fat-saturated diffusion-weighted imaging via a periodically rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) technique.Results: Parotid fat content was larger in men than in women by about 10 percentage points (P < 0.005), and positively associated with BMI and age for both genders (mostly with P < 0.001). ADCs estimated with non-fat-saturated PROPELLER were significantly lower in men than in women (P < 0.005), but showed no gender difference if measured using fat-saturated PROPELLER (P = 0.840). The negative association between parotid ADC and age/BMI/fat (P < 0.001) showed greater regression slopes in non-fat-saturated PROPELLER than in fat-saturated data.Conclusions: Parotid fat content in healthy adults correlates positively with both age and BMI; the correlation with age is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation.Key Points: Parotid fat content in healthy adults correlates positively with age and BMI. The rate of aging-related increase in fat contents is gender-dependent. Parotid ADC measurements are strongly influenced by fat saturation. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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