Increased intragraft rejection-associated gene transcripts in patients with donor-specific antibodies and normal biopsies.
We investigated why some donor-specific antibody-positive patients do not develop antibody-mediated rejection. Of 71 donor-specific antibody-positive patients, 46 had diagnosis of antibody-mediated rejection and 25 had normal biopsies. Fifty donor-specific antibody-negative patients with normal biop...
| Publicado en: | Kidney International Vol. 86; no. 3; pp. 600 - 610 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Sep2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103843590&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103843590 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00852538 4CU jtl: Kidney International issn: 00852538 maglogo: N pubinfo: dt: Sep2014 vid: 86 iid: 3 pid: 82545 pub: Elsevier B.V. place: Philadelphia, Pennsylvania artinfo: ui: 103843590 2012706743 10.1038/ki.2014.75 NLM24670411 103843590 ppf: 600 ppct: 10 formats: tig: atl: Increased intragraft rejection-associated gene transcripts in patients with donor-specific antibodies and normal biopsies. aug: au: Hayde, Nicole Broin, Pilib O Bao, Yi de Boccardo, Graciela Lubetzky, Michelle Ajaimy, Maria Pullman, James Colovai, Adriana Golden, Aaron Akalin, Enver affil: Division of Pediatric Nephrology, University of Texas Health Science Center, Houston, Texas, USA. sug: subj: Antibodies Blood Graft Rejection Graft Rejection Immunology HLA Antigens Immunology Kidney Transplantation RNA Analysis RNA Immunity Adult B Lymphocytes Immunology Female Gene Expression Profiling Kidney Immunology Male Middle Age Oligonucleotide Array Sequence Analysis T Lymphocytes Immunology Transplantation Immunology Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: We investigated why some donor-specific antibody-positive patients do not develop antibody-mediated rejection. Of 71 donor-specific antibody-positive patients, 46 had diagnosis of antibody-mediated rejection and 25 had normal biopsies. Fifty donor-specific antibody-negative patients with normal biopsies were used as a control group. A subgroup of 61 patients with available biopsy and 64 with blood samples were analyzed by microarrays. Both donor-specific antibody-positive/antibody-mediated rejection-positive and negative biopsies showed increased expression of gene transcripts associated with cytotoxic T cells, natural killer cells, macrophages, interferon-gamma, and rejection compared to donor-specific antibody-negative biopsies. Regulatory T-cell transcripts were upregulated in donor-specific antibody-positive/antibody-mediated rejection-positive and B-cell transcripts in donor-specific antibody-positive/antibody-mediated rejection-negative biopsies. Whole-blood gene expression analysis showed increased immune activity in only donor-specific antibody-positive/antibody-mediated rejection-positive but not negative patients. During a median follow-up of 36 months, 4 donor-specific antibody-positive/antibody-mediated rejection-negative patients developed antibody-mediated rejection, 12 continued to have donor-specific antibody, but 9 lost their donor-specific antibody. Gene expression profiles did not predict the development of antibody-mediated rejection or the persistence of donor-specific antibody. Thus, donor-specific antibody-positive/antibody-mediated rejection-negative patients had increased rejection-associated gene transcripts in their allografts despite no histologic findings of rejection but not in their blood. This was found in both biopsy and blood samples of donor-specific antibody-positive/antibody-mediated rejection-positive patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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