The effect of local anatomy on the electric field induced by TMS: evaluation at 14 different target sites.
Many human cortical regions are targeted with transcranial magnetic stimulation (TMS). The stimulus intensity used for a certain region is generally based on the motor threshold stimulation intensity determined over the motor cortex (M1). However, it is well known that differences exist in coil-targ...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 52; no. 10; pp. 873 - 884 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103846404&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103846404 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Oct2014 vid: 52 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103846404 NLM25163822 2012734639 10.1007/s11517-014-1190-6 NLM25163822 103846404 ppf: 873 ppct: 11 formats: fmt: @attributes: type: P tig: atl: The effect of local anatomy on the electric field induced by TMS: evaluation at 14 different target sites. aug: au: Janssen, Arno M Oostendorp, Thom F Stegeman, Dick F affil: Department of Neurology/Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Reinier Postlaan 4, 6525 CG, Nijmegen, The Netherlands, Arno.Janssen@radboudumc.nl. sug: subj: Cerebral Cortex Anatomy and Histology Cerebral Cortex Physiology Electricity Transcranial Magnetic Stimulation Adult Cerebrospinal Fluid Physiology Electrophysiology Gray Matter Anatomy and Histology Gray Matter Physiology Magnetic Resonance Imaging Male Adult: 19-44 years Male ab: Many human cortical regions are targeted with transcranial magnetic stimulation (TMS). The stimulus intensity used for a certain region is generally based on the motor threshold stimulation intensity determined over the motor cortex (M1). However, it is well known that differences exist in coil-target distance and target site anatomy between cortical regions. These differences may well make the stimulation intensity derived from M1 sub-optimal for other regions. Our goal was to determine in what way the induced electric fields differ between cortical target regions. We used finite element method modeling to calculate the induced electric field for multiple target sites in a realistic head model. The effects on the electric field due to coil-target distance and target site anatomy have been quantified. The results show that a correction based on the distance alone does not correctly adjust the induced electric field for regions other than M1. In addition, a correction based solely on the TMS-induced electric field (primary field) does not suffice. A precise adjustment should include coil-target distance, the secondary field caused by charge accumulation at conductivity discontinuities and the direction of the field relative to the local cerebrospinal fluid-grey matter boundary. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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