Intra-vascular blood velocity and volumetric flow rate calculated from dynamic 4D CT angiography using a time of flight technique.
We examine a time of flight (TOF) approach for the analysis of contrast enhanced 4D volumetric CT angiography scans to derive and display blood velocity in arteries. Software was written to divide blood vessels into a series of cross sections and to track contrast bolus TOF along the central vessel...
| Publicado en: | International Journal of Cardiovascular Imaging Vol. 30; no. 7; pp. 1383 - 1393 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Oct2014
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103846666&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103846666 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15695794 1HHY jtl: International Journal of Cardiovascular Imaging issn: 15695794 maglogo: N pubinfo: dt: Oct2014 vid: 30 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103846666 NLM25001895 2012735540 10.1007/s10554-014-0471-3 NLM25001895 103846666 ppf: 1383 ppct: 10 formats: tig: atl: Intra-vascular blood velocity and volumetric flow rate calculated from dynamic 4D CT angiography using a time of flight technique. aug: au: Barfett, Joseph John Velauthapillai, Nivethan Fierstra, Jorn Crawley, Adrian Coolens, Catherine Crean, Andrew Jaskolka, Jeff Dufort, Paul Krings, Timo Mikulis, David affil: Department of Medical Imaging, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada, barfettj@smh.ca. sug: subj: Angiography Methods Tomography, X-Ray Computed Equipment and Supplies Hemodynamics Radiographic Image Interpretation, Computer-Assisted Aged Aged, 80 and Over Algorithms Angiography Equipment and Supplies Blood Flow Velocity Cerebral Arteries Physiopathology Cerebral Arteries Radiography Cerebrovascular Circulation Contrast Media Diagnostic Use Female Human Iliac Artery Physiopathology Iliac Artery Radiography Male Middle Age Models, Biological Phantoms, Imaging Predictive Value of Tests Pulmonary Artery Physiopathology Pulmonary Artery Radiography Pulmonary Circulation Blood Circulation Retrospective Design Software Subclavian Steal Syndrome Physiopathology Subclavian Steal Syndrome Radiography Time Factors Vertebral Artery Physiopathology Vertebral Artery Radiography Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: We examine a time of flight (TOF) approach for the analysis of contrast enhanced 4D volumetric CT angiography scans to derive and display blood velocity in arteries. Software was written to divide blood vessels into a series of cross sections and to track contrast bolus TOF along the central vessel axis, which was defined by a user, from 4D CT source data. Time density curves at each vessel cross section were fit with quadratic, Gaussian, and gamma variate functions to determine bolus time to peak (TTP). A straight line was used to plot TTP versus vessel path length for all three functions and the slope used to calculate intraluminal velocity. Software was validated in a simulated square channel and non-pulsatile flow phantom prior to the calculation of blood velocity in the major cerebral arteries of 8 normal patients. The TOF algorithm correctly calculates intra-luminal fluid velocity in eight flow conditions of the CT flow phantom where quadratic functions were used. Across all conditions, in phantoms and in vivo, the success of calculations depended strongly on having a sufficiently long path length to make measurements and avoiding venous contamination. Total blood flow into the brain was approximately 17 % of a normal 5 L cardiac output. The technique was explored in vivo in a patient with subclavian steal syndrome, in the pulmonary arteries and in the iliac artery from clinical 4D CT source data. Intravascular blood velocity and flow may be calculated from 4D CT angiography using a TOF approach. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|