Association between antiretroviral therapy adherence and employment status: systematic review and meta-analysis.
Objective. To assess the association between the employment status of human immunodeficiency virus (HIV)-infected individuals and adherence to antiretroviral therapy (ART). Methods. We searched the Medline, Embase and Cochrane Central Register of Controlled Trials databases for studies reporting ART...
| Published in: | Bulletin of the World Health Organization Vol. 93; no. 1; pp. 29 - 42 |
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| Main Authors: | , , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
World Health Organization
Jan2015
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103870332&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103870332 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00429686 BUW jtl: Bulletin of the World Health Organization issn: 00429686 maglogo: N pubinfo: dt: Jan2015 vid: 93 iid: 1 pid: 437 pub: World Health Organization artinfo: ui: 103870332 100254782 10.2471/BLT.14.138149 NLM25558105 103870332 ppf: 29 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Association between antiretroviral therapy adherence and employment status: systematic review and meta-analysis. aug: au: Nachega, Jean B. Uthman, Olalekan A. Peltzer, Karl Richardson, Lindsey A. Mills, Edward J. Amekudzi, Kofi Ouédraogo, Alice affil: Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, 503 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States of America (USA) sug: subj: AIDS Patients Evaluation Anti-Retroviral Agents Administration and Dosage Medication Compliance Evaluation Employment Status Funding Source Human Meta Analysis Systematic Review Descriptive Statistics Odds Ratio Confidence Intervals Chi Square Test P-Value Data Analysis, Statistical Data Analysis Software Regression Male Female Adult Middle Age Aged Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Objective. To assess the association between the employment status of human immunodeficiency virus (HIV)-infected individuals and adherence to antiretroviral therapy (ART). Methods. We searched the Medline, Embase and Cochrane Central Register of Controlled Trials databases for studies reporting ART adherence and employment status published between January 1980 and September 2014. Information from a wide range of other sources, including the grey literature, was also analysed. Two independent reviewers extracted data on treatment adherence and study characteristics. Study data on the association between being employed and adhering to ART were pooled using a random-effects model. Between-study heterogeneity and sources of bias were evaluated. Findings. The meta-analysis included 28 studies published between 1996 and 2014 that together involved 8743 HIV-infected individuals from 14 countries. The overall pooled odds ratio (OR) for the association between being employed and adhering to ART was 1.27 (95% confidence interval, CI: 1.04–1.55). The association was significant for studies from low-income countries (OR: 1.85, 95% CI: 1.58–2.18) and high-income countries (OR: 1.33, 95% CI: 1.02–1.74) but not middle-income countries (OR: 0.94, 95% CI: 0.62–1.42). In addition, studies published after 2011 and larger studies showed less association between employment and adherence than earlier and small studies, respectively. Conclusion. Employed HIV-infected individuals, particularly those in low- and high-income countries, were more likely to adhere to ART than unemployed individuals. Further research is needed on the mechanisms by which employment and ART adherence affect each other and on whether employment-creation interventions can positively influence ART adherence, HIV disease progression and quality of life. a Department pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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