Effects of Topical Diclofenac Plus Heparin (Dhep+H Plaster) on Somatic Pain Sensitivity in Healthy Subjects With a Latent Algogenic Condition of the Lower Limb.
Objective To evaluate whether a diclofenac epolamine + heparin topical (plaster) is more effective than diclofenac plaster alone in reducing deep somatic hyperalgesia in subjects without spontaneous pain and whether the effect is linked to or independent of the anti-edematous action of heparin. Desi...
| Publicado en: | Pain Practice Vol. 15; no. 1; pp. 58 - 68 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103870424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103870424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307085 HYN jtl: Pain Practice issn: 15307085 maglogo: Y pubinfo: dt: Jan2015 vid: 15 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103870424 100256860 10.1111/papr.12161 NLM24433223 103870424 ppf: 58 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Effects of Topical Diclofenac Plus Heparin (Dhep+H Plaster) on Somatic Pain Sensitivity in Healthy Subjects With a Latent Algogenic Condition of the Lower Limb. aug: au: Affaitati, Giannapia Fabrizio, Alessandra Frangione, Valeria Lanzarotti, Arturo Lopopolo, Mariangela Tafuri, Emmanuele Lapenna, Domenico Giamberardino, Maria Adele Costantini, Raffaele affil: Ce.S.I., 'G. D'Annunzio' Foundation; Department of Medicine and Science of Aging, University of Chieti sug: subj: Diclofenac Administration and Dosage Heparin Drug Combinations Administration, Topical Muscle Pain Prevention and Control Hyperalgesia Drug Therapy Pain Threshold Leg Pathology Human Randomized Controlled Trials Prospective Studies Double-Blind Studies Female Male Descriptive Statistics Random Assignment Academic Medical Centers Italy Adolescence Young Adult Adult Middle Age Aged Algometry Methods Electric Stimulation Methods Data Analysis Software T-Tests Analysis of Variance Post Hoc Analysis Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objective To evaluate whether a diclofenac epolamine + heparin topical (plaster) is more effective than diclofenac plaster alone in reducing deep somatic hyperalgesia in subjects without spontaneous pain and whether the effect is linked to or independent of the anti-edematous action of heparin. Design Prospective, double-blind, randomized and controlled, four-arm parallel design trial. Subjects One hundred and four patients (84 women, 20 men, mean age 42.2 ± 13.3 years), with deep somatic hyperalgesia in one thigh, randomly assigned to one of 4 groups of 26 each. Intervention Each group underwent one of the following plaster treatments on one thigh: diclofenac+heparin; diclofenac; heparin; placebo, for 7 days, renewing the plaster every 24 hours. Outcome Measures Before treatment (day 1), at day 4 and day 8, assessment of (a) pressure and electrical pain thresholds of vastus lateralis and overlying subcutis and skin; and (b) structure/thickness of subcutis and muscle with ultrasounds at the same level. Results During treatment, in placebo and heparin, no significant threshold changes, except subcutis thresholds which increased slightly ( P < 0.02); in diclofenac and diclofenac+heparin, significant increase in all thresholds (0.0001 < P < 0.04). Electrical muscle pain thresholds increased significantly more in diclofenac+heparin than in diclofenac, heparin, and placebo (0.0001 < P < 0.04). In all groups: no edema and thickness changes at ultrasounds in muscle and subcutis. Conclusions Topical diclofenac+heparin is significantly more effective than diclofenac alone in reducing muscle hyperalgesia in subjects without spontaneous pain, independently of the anti-edematous action of heparin. The results provide a rationale for the use of diclofenac+heparin also in algogenic conditions without evident signs of injury/edema/hematoma. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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