Impact of microscopic duodenitis on symptomatic response to Helicobacter pylori eradication in functional dyspepsia.
Background and Aim: There is no consensus regarding the benefit of eradicating Helicobacter pylori (H. pylori) infection in patients with functional dyspepsia (FD). We intended to compare the symptom response to H. pylori eradication in FD patients in presence or absence of microscopic duodenitis (M...
| Publicado en: | Digestive Diseases & Sciences Vol. 60; no. 1; pp. 163 - 168 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jan2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103874390&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103874390 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01632116 1VP jtl: Digestive Diseases & Sciences issn: 01632116 maglogo: N pubinfo: dt: Jan2015 vid: 60 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 103874390 NLM25102980 2012870454 10.1007/s10620-014-3285-1 NLM25102980 103874390 ppf: 163 ppct: 5 formats: tig: atl: Impact of microscopic duodenitis on symptomatic response to Helicobacter pylori eradication in functional dyspepsia. aug: au: Mirbagheri, Seyed Sina Mirbagheri, Seyed Amir Nabavizadeh, Behnam Entezari, Pouya Ostovaneh, Mohammad Reza Hosseini, Seyed Mahmood Eshagh Rakhshani, Nasser Safa, Hoda affil: Division of Gastroenterology, Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, North Sa'adi Street, 13145-784, Tehran, Iran. sug: subj: Duodenal Diseases Pathology Helicobacter Infections Drug Therapy Helicobacter Pylori Drug Effects Adult Breath Tests Clinical Assessment Tools Dyspepsia Female Helicobacter Infections Complications Helicobacter Infections Pathology Human Immunohistochemistry Male Metaplasia Questionnaires Treatment Outcomes Adult: 19-44 years Female Male ab: Background and Aim: There is no consensus regarding the benefit of eradicating Helicobacter pylori (H. pylori) infection in patients with functional dyspepsia (FD). We intended to compare the symptom response to H. pylori eradication in FD patients in presence or absence of microscopic duodenitis (MD).Methods: Patients with dyspepsia, normal upper gastrointestinal endoscopy and no psychological comorbidity according to the 12-item General Health Questionnaire underwent duodenal biopsy sampling. Of those, subjects with positive rapid urease test and H. pylori colonization in Wright-Giemsa staining were included in the study and evaluated histologically for presence of MD. All patients received sequential H. pylori eradication therapy and underwent urea breath test 4 weeks after the completion of the treatment to confirm the H. pylori eradication. The severity of dyspepsia was assessed using the Leeds Dyspepsia Questionnaire (LDQ) at baseline, 3rd and 6th months after the H. pylori infection was eradicated.Results: Thirty seven patients were included in the study [mean age: 34.9 (8.1), 54.05 % female]. MD was observed in 16 (43.2 %) of the subjects. The mean LDQ score in patients with MD decreased from 12.5 (4.1) at baseline to 4.3 (2.1) at 3rd month and 2.6 (1.9) at 6th month. In patients without microscopic duodenitis, the mean LDQ score decreased from 10.6 (5.2) at baseline to 6.8 (4.1) and 6.2 (3.8) at 3rd and 6th months, respectively. The improvement in severity of symptoms in presence of MD was significantly greater than when it was absent (P < 0.001).Conclusion: FD patients with MD achieved greater symptomatic response with H. pylori eradication than those without microscopic duodenitis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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