Infant botulism due to C. butyricum type E toxin: a novel environmental association with pet terrapins.
We describe two cases of infant botulism due to Clostridium butyricum producing botulinum type E neurotoxin (BoNT/E) and a previously unreported environmental source. The infants presented at age 11 days with poor feeding and lethargy, hypotonia, dilated pupils and absent reflexes. Faecal samples we...
| Publicado en: | Epidemiology & Infection Vol. 143; no. 3; pp. 461 - 470 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Cambridge University Press
Feb2015
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103876005&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103876005 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09502688 2S0 jtl: Epidemiology & Infection issn: 09502688 maglogo: N pubinfo: dt: Feb2015 vid: 143 iid: 3 pid: 15979 pub: Cambridge University Press artinfo: ui: 103876005 NLM25306863 2012876259 10.1017/S0950268814002672 NLM25306863 103876005 ppf: 461 ppct: 9 formats: tig: atl: Infant botulism due to C. butyricum type E toxin: a novel environmental association with pet terrapins. aug: au: Shelley, E B O'Rourke, D Grant, K McARDLE, E Capra, L Clarke, A McNAMARA, E Cunney, R McKEOWN, P Amar, C F L Cosgrove, C Fitzgerald, M Harrington, P Garvey, P Grainger, F Griffin, J Lynch, B J McGRANE, G Murphy, J Ni Shuibhne, N sug: subj: Botulinum Toxins Analysis Botulism Diagnosis Botulism Pathology Clostridium Feces Animals Antitoxins Therapeutic Use Botulism Therapy Great Britain Infant, Newborn Male Genetic Techniques Pets Reptiles Treatment Outcomes Water Microbiology Infant, Newborn: birth-1 month Male ab: We describe two cases of infant botulism due to Clostridium butyricum producing botulinum type E neurotoxin (BoNT/E) and a previously unreported environmental source. The infants presented at age 11 days with poor feeding and lethargy, hypotonia, dilated pupils and absent reflexes. Faecal samples were positive for C. butyricum BoNT/E. The infants recovered after treatment including botulism immune globulin intravenous (BIG-IV). C. butyricum BoNT/E was isolated from water from tanks housing pet 'yellow-bellied' terrapins (Trachemys scripta scripta): in case A the terrapins were in the infant's home; in case B a relative fed the terrapin prior to holding and feeding the infant when both visited another relative. C. butyricum isolates from the infants and the respective terrapin tank waters were indistinguishable by molecular typing. Review of a case of C. butyricum BoNT/E botulism in the UK found that there was a pet terrapin where the infant was living. It is concluded that the C. butyricum-producing BoNT type E in these cases of infant botulism most likely originated from pet terrapins. These findings reinforce public health advice that reptiles, including terrapins, are not suitable pets for children aged <5 years, and highlight the importance of hand washing after handling these pets. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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