Treatment Planning Methods in High Dose Rate Interstitial Brachytherapy of Carcinoma Cervix: A Dosimetric and Radiobiological Analysis.
Treatment planning is a trial and error process that determines optimal dwell times, dose distribution, and loading pattern for high dose rate brachytherapy Planning systems offer a number of dose calculation methods to either normalize or optimize the radiation dose. Each method has its own charact...
| Publicado en: | ISRN Oncology pp. 1 - 6 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103879962&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103879962 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20905661 BLI2 jtl: ISRN Oncology issn: 20905661 maglogo: N pubinfo: dt: 2014 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 103879962 103879962 2012858651 103879962 ppf: 1 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Treatment Planning Methods in High Dose Rate Interstitial Brachytherapy of Carcinoma Cervix: A Dosimetric and Radiobiological Analysis. aug: au: Anbumani, Surega Anchineyan, Pichandi Narayanasamy, ArunaiNambiraj Palled, Siddanna R. Sathisan, Sajitha Jayaraman, Punitha Selvi, Muthu Bilimagga, Ramesh S. affil: Department of Radiation Oncology, HCG Bangalore Institute of Oncology, RRMR Extension KH Road, Bangalore 560027, India sug: subj: Cervix Neoplasms Radiotherapy Brachytherapy Utilization Dose-Response Relationship Human Academic Medical Centers India Strategic Planning Pearson's Correlation Coefficient Radiotherapy, Conformal Cervix Neoplasms Epidemiology Tomography T-Tests Data Analysis Software Confidence Intervals Analysis of Variance Regression ab: Treatment planning is a trial and error process that determines optimal dwell times, dose distribution, and loading pattern for high dose rate brachytherapy Planning systems offer a number of dose calculation methods to either normalize or optimize the radiation dose. Each method has its own characteristics for achieving therapeutic dose to mitigate cancer growth without harming contiguous normal tissues. Our aim is to propose the best suited method for planning interstitial brachytherapy. 40 cervical cancer patients were randomly selected and 5 planning methods were iterated. Graphical optimization was compared with implant geometry and dose point normalization/optimization techniques using dosimetrical and radiobiological plan quality indices retrospectively. Mean tumor control probability was similar in all the methods with no statistical significance. Mean normal tissue complication probability for bladder and rectum is 0.3252 and 0.3126 (P = 0.0001), respectively, in graphical optimized plans compared to other methods. There was no significant correlation found between Conformity Index and tumor control probability when the plans were ranked according to Pearson product moment method (r = -0.120). Graphical optimization can result in maximum sparing of normal tissues. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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