Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort.
Background: Persistent organic pollutants (POPs) are compounds that are generated through various industrial activities and released in the surrounding environment. Different animal studies have shown effects of different POPs on various inflammatory markers. Objective: Because very few studies have...
| Publicado en: | Environmental Health Perspectives Vol. 122; no. 9; pp. 977 - 984 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Sep2014
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=103890235&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 103890235 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Sep2014 vid: 122 iid: 9 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 103890235 98020222 10.1289/ehp.1307613 NLM24911359 103890235 ppf: 977 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort. aug: au: Kumar, Jitender Lind, P. Monica Salihovic, Samira van Bavel, Bert Ingelsson, Erik Lind, Lars affil: Molecular Epidemiology & Science for Life Laboratory, Uppsala University, Uppsala, Sweden sug: subj: Environmental Pollutants Immunology Organic Chemicals Immunology Biological Markers Blood Inflammation Blood Human Cross Sectional Studies Female Male Aged Sweden Funding Source Blood Chemical Analysis Methods Questionnaires Linear Regression Data Analysis Software Aged: 65+ years Female Male ab: Background: Persistent organic pollutants (POPs) are compounds that are generated through various industrial activities and released in the surrounding environment. Different animal studies have shown effects of different POPs on various inflammatory markers. Objective: Because very few studies have been conducted in humans, we assessed the associations between different POPs and inflammatory markers in a large population-based sample of elderly men and women (all 70 years of age) from Sweden. Methods: This cross-sectional study investigated the concentrations of several polychlorinated biphenyls (PCBs), organochlorine pesticides, polychlorinated dibenzo-p-dioxin, and brominated diphenyl ether congeners and their association with a number of inflammatory markers [vascular cell adhesion molecule 1 (VCAM‑1), intercellular adhesion molecule 1 (ICAM‑1), E‑selectin, C-reactive protein (CRP), total leucocyte count, tumor necrosis factor α (TNF‑α), monocyte chemotactic protein 1 (MCP‑1), and interleukin 6 (IL‑6)] in 992 individuals. These individuals were recruited from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. We used a total toxic equivalency (TEQ) value that measures toxicological effects with the relative potencies of various POPs. Results: Following adjustment for potential confounders, the TEQ value (driven mainly by PCB‑126) was significantly associated with levels of ICAM-1 (p < 10–5). A similar trend was also observed between sum of PCBs and VCAM-1 (p < 0.001). No significant associations were observed between levels of POPs and other inflammatory markers. Conclusions: TEQ values were associated with levels of ICAM-1, to a lesser degree also with VCAM-1, but not with CRP and several other inflammatory markers. These findings suggest an activation of vascular adhesion molecules by POPs, and particularly by PCB-126. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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